neurofilament phosphorylation
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[P4-129]: A VASCULOCENTRIC PATTERN OF AXONAL DAMAGE AND NEUROFILAMENT PHOSPHORYLATION IN SUBCORTICAL WHITE MATTER OF OLDER PEOPLE

2017 ◽  
Vol 13 (7S_Part_27) ◽  
pp. P1305-P1306
Author(s):  
Miriam Barker ◽  
Leslie Bridges ◽  
Margaret Esiri ◽  
Atticus H. Hainsworth
Keyword(s):  
White Matter ◽  
Older People ◽  
Subcortical White Matter ◽  
Axonal Damage ◽  
Neurofilament Phosphorylation

scholarly journals Delayed Nerve Stimulation Promotes Axon-Protective Neurofilament Phosphorylation, Accelerates Immune Cell Clearance and Enhances Remyelination In Vivo in Focally Demyelinated Nerves

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e110174 ◽  
Author(s):  
Nikki A. McLean ◽  
Bogdan F. Popescu ◽  
Tessa Gordon ◽  
Douglas W. Zochodne ◽  
Valerie M. K. Verge
Keyword(s):  
Nerve Stimulation ◽  
Immune Cell ◽  
Cell Clearance ◽  
Neurofilament Phosphorylation

scholarly journals Suppression of Extensive Neurofilament Phosphorylation Rescues α-Internexin/Peripherin-Overexpressing PC12 Cells from Neuronal Cell Death

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43883 ◽  
Author(s):  
Wen-Ching Lee ◽  
Daphne Kan ◽  
Yun-Yu Chen ◽  
Shan-Kuo Han ◽  
Kuo-Shyan Lu ◽  
...  
Keyword(s):  
Cell Death ◽  
Pc12 Cells ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Neurofilament Phosphorylation

scholarly journals The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers

2006 ◽  
Vol 12 (3) ◽  
pp. 325-328 ◽  
Author(s):  
A Petzold ◽  
M J Eikelenboom ◽  
G Keir ◽  
C H Polman ◽  
B MJ Uitdehaag ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Disease Severity ◽  
Heavy Chain ◽  
Severity Score ◽  
Severity Scale ◽  
Cerebrospinal Fluid Biomarkers ◽  
Neurofilament Phosphorylation ◽  
Disabled Patients

This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology. The MSSS correlated with the phosphorylated neurofilament heavy chain (NfH-SMI35, R=0.44, P=0.016). The degree of neurofilament phosphorylation (ratio NfH-SMI34 to NfH-SMI35) was 8-fold higher in severely (median MSSS 6.5) versus mildly (MSSS 3.2) disabled patients (7.3 versus 0.9, P=0.03). The MSSS may provide a statistically powerful tool for comparing overall disease severity and be useful for validating the biomarker concept in MS.

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