Multicity Investigation of the Effect of Holidays on Bikeshare System Ridership

Bikeshare provides important first mile–last mile, commuting, circulation, and sightseeing options in many cities. Bikeshare can also be healthy and convenient for users. Throughout the year, holidays occur that change typical bikeshare activity patterns. Existing literature shows mixed results relating to the ridership impacts of holidays: some research shows that these days may result in higher ridership, whereas others show no effect. Because of variations in system locations and modeling methods, it is difficult to determine the reasons for these mixed results. To control for these aspects, this project consisted of a multicity study of the effect of holidays on system-level ridership using a loglinear regression model with robust standard errors. The results showed the impacts of holidays on bikeshare system ridership for different user types among systems in the Washington D.C., Chicago, Boston, Los Angeles, and Minneapolis metro areas. Several hypotheses were developed and tested to examine the effects of holidays on bikeshare usage. A major finding from this study was that federal holidays negatively affected member ridership and positively affected nonmember ridership. It was also found that different federal holidays had dissimilar effects on total ridership. These findings could be useful for bikeshare agencies to plan, reposition fleet, and improve system operation.

IMMUNOLOGICAL AND EPIDEMIOLOGICAL STUDY OF HYDATID CYSTS DISEASE IN ADULT PATIENTS

Hydatid cysts disease is considered one of the important common diseases between humans and animals that have pathological effects with serious complications. The current study was conducted during the period from February 2020 to August to investigate hydatid worm infections and the associated environmental factors, and the current study was concerned with evaluating the number of cases of disease in hydatid cysts in general hospital of Al-Diwaniyah governorate, and identifying the organs that were targeted by the infection. The current study was also conducted to investigate the extent of the immune responses that the body develops against the hydatid cysts.40 patients (11 males and 29 females) infected with confirmed cystic echinococcosis and 10 apparently healthy as a control group, that the most affected member is (Liver), as the rate of infection (42,5), and (30%) in kidney and ( 27,5%) in spleen. IgG ELISA was performed to assess humoral immune responses. the results showed the sensitivity of the ELISA test to detect anti-hydatid antibodies was be 82.45%.

Epidemiology of craniosynostosis in Norway

OBJECTIVEThe authors present population-based epidemiological data for craniosynostosis regarding incidence, age at diagnosis, sex differences, and frequency of syndromic and familial cases.METHODSThe prospective registry of the Norwegian National Unit for Craniofacial Surgery was used to retrieve data on all individuals with craniosynostosis treated between 2003 and 2017. The cohort was divided into three 5-year groups based on year of birth: 2003–2007, 2008–2012, and 2013–2017.RESULTSThe authors identified 386 individuals with craniosynostosis. Of these, 328 (85%) consented to be registered with further information. The incidence increased significantly during the study period and was 5.5 per 10,000 live births (1/1800) in the last 5-year period. The increase was seen almost exclusively in the nonsyndromic group. Syndromic craniosynostosis accounted for 27% of the cases, and the incidence remained stable throughout the three 5-year periods. Both syndromic and nonsyndromic craniosynostosis were highly suture specific. There was a male preponderance (male/female ratio 2:1), and males accounted for 75% of the individuals with midline synostosis. Overall, 9.5% were index individuals in families with more than one affected member; of these, 73% were nonsyndromic cases.CONCLUSIONSThe incidence of craniosynostosis increased during the study period, and the observed incidence is among the highest reported. The authors attribute this to increasing awareness among healthcare professionals. The number of syndromic cases was high, likely due to a broader definition compared to the majority of earlier reports. The study revealed a high number of familial cases in both syndromic and nonsyndromic craniosynostosis, thus highlighting the importance of genetics as an underlying cause of craniosynostosis.

Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31

We report a genomic and phenotypic delineation for two chromosome regions with candidate genes for syndromic intellectual disability at 12q12 and Xp22.31, segregating independently in one family with four affected members. Fine mapping of three affected members, along with six unreported small informative CNVs, narrowed down the candidate chromosomal interval to one gene LRRK2 at 12q12. Expression studies revealed high levels of LRRK2 transcripts in the whole human brain, cerebral cortex and hippocampus. RT-qPCR assays revealed that LRRK2 transcripts were dramatically reduced in our microdeletion patient DGDP289A compared to his healthy grandfather with no deletion. The decreased expression of LRRK2 may affect protein–protein interactions between LRRK2 and its binding partners, of which eight have previously been linked to intellectual disability. These findings corroborate with a role for LRRK2 in cognitive development, and, thus, we propose that intellectual disability and autism, displayed in the 12q12 microdeletions, are likely caused by LRRK2. Using another affected member, DGDP289B, with a microdeletion at Xp22.31, in this family, we performed the genomic and clinical delineation with six published and nine unreported cases. We propose HDHD1 and PNPLA4 for X-linked intellectual disability in this region, since their high transcript levels in the human brain substantiate their role in intellectual functioning.

Through a Glass Darkly: The icc, the unsc and the Quest for Justice in International Law

Despite the aspirations of the International Criminal Court (icc), it is unlikely to achieve an end to impunity for crimes of concern to the international community without acknowledgement of and due engagement with the politics of international criminal law. A major threat to the legitimacy of the Court is its relationship with the United Nations Security Council (unsc). unsc referrals of conflict situations under Article 13(b) of the Rome Statute remain subject to geo-political considerations. The exercise is thus arbitrary at best, and may render the icc an instrument of political coercion at worst. An apolitical approach to conflicts given this context is almost antithetical to justice and has already given rise to tensions between the Court and some affected member states. Managing the asymmetry created by unsc referrals and rethinking its seemingly unjustified encroachment in the affairs of less influential states should become the priority for the Court.

MEN1 gene mutation with parathyroid carcinoma: first report of a familial case

Background The occurrence of parathyroid carcinoma in multiple endocrine neoplasia type I (MENI) is rare and the 15 cases of malignant parathyroid tumor reported so far have been associated with MENI in individuals and not with multiple members within a family. Methods We report on a 61-year-old male, operated for a 7.3 cm parathyroid carcinoma infiltrating the esophagus. In his brother, a 4.6 cm parathyroid carcinoma was diagnosed histologically, while in the daughter, neck ultrasonography revealed 2 extrathyroidal nodules, yet to be excised. Results Screening of the MEN1 gene identified a known germline heterozygous missense mutation (c.1252G>A; p.D418N) in exon 9, in all affected subjects. Conclusions The occurrence of parathyroid carcinoma in more than one affected member of a single MEN1 family represents the first reported familial case. This suggests that additional constitutional genetic mutations may contribute to the variation in malignant potential and clinical behavior of parathyroid tumors in MEN1.

Unilateral vestibular schwannoma in a patient with schwannomatosis in the absence of LZTR1 mutation

The presence of vestibular schwannomas has long been considered an exclusion criterion for the diagnosis of schwannomatosis. Recently, 2 cases of vestibular schwannoma were reported in patients with schwannomatosis, leading to a revision of the diagnostic criteria for this genetic disorder. Overall, the relative infrequency of vestibular schwannomas in schwannomatosis is unexplained, and the genetics of this uncommon phenomenon have not been described. The authors report on a family with clinical manifestations consistent with schwannomatosis, including 4 affected members, that was identified as having an affected member harboring a unilateral cerebellopontine angle mass with extension into the internal auditory canal. Radiologically, this mass was consistent with a vestibular schwannoma and resulted in a symptomatic change in ipsilateral hearing (word recognition 86% at 52 dB) and increased latency of the wave I–V interval on auditory brainstem response testing. The patient was found to be negative for a germline mutation of NF2 and LZTR1, and her affected mother was found to harbor neither NF2 nor SMARCB1 mutations on genetic testing. Although vestibular schwannomas have been classically considered to not occur in the setting of schwannomatosis, this patient with schwannomatosis and a vestibular schwannoma further confirms that schwannomas can occur on the vestibular nerve in this syndrome. Further, this is the first such case found to be negative for a mutation on the LZTR1 gene.

THE EU’S HOTSPOT APPROACH TO MANAGING THE MIGRATION CRISIS: A BLIND SPOT FOR INTERNATIONAL RESPONSIBILITY?

Announced by the European Commission in its 2015 European Agenda on Migration as one of the EU’s priority tools to face the “unprecedented” migration crisis the Union was experiencing, the “hotspot” approach consists of a common platform for EU agencies (namely, the European Asylum Support Office, Frontex, Eurojust, and Europol) to intervene, rapidly and in an integrated manner, in frontline Member States when there is a crisis due to specific and disproportionate migratory pressure at their external borders. The goal was to reduce the pressure at the borders of the most affected Member States to “normal” levels while ensuring the proper reception, identification, and processing of arrivals. The present contribution makes some introductory remarks on issues of international responsibility under international law emerging from the implementation – by State and EU actors – of the hotspot approach. In particular, the analysis will focus on problems related to the attribution of conduct, in light of the large number of subjects involved in the relevant activities. In this respect, this contribution will highlight first the function of hotspots. Then, the discussion will analyze the position of different actors involved in the hotspot approach in light of the international law framework on international responsibility. An assessment of what has been discussed in the preceding sections is contained in the final part.

Disproportionate Migration Pressure as a Challenge for the National Security of the Republic of Bulgaria

Since 2011 a sustainable growth of illegal immigrants in the EU has been observed. As a result, Bulgaria has become one of the most affected member states of the EU. This article aims to research the main factors, resulted from the illegal immigration, which are changing the national security environment in Bulgaria. This paper is focused on the improvement of legal and political mechanisms for cooperation between the EU member states, coming from the Common asylum and immigration policy and building of the Area of Freedom, Security and Justice in the EU.