tropheryma whippelii
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2021 ◽  
Vol 02 (03) ◽  
Author(s):  
Díaz-Cañestro M ◽  
Camprodón A ◽  
Vidal-Lampurdanes M ◽  
Ramos-Asensio R ◽  
Riera M ◽  
...  

2006 ◽  
Vol 27 (5) ◽  
pp. 507-508 ◽  
Author(s):  
Jin-Wuk Hur ◽  
Young-In Na ◽  
Tae-Hwan Kim ◽  
Shin-Young Yim ◽  
Jae-Bum Jun

2006 ◽  
Vol 64 (3b) ◽  
pp. 865-868 ◽  
Author(s):  
Luís F. Maia ◽  
Mónica Marta ◽  
Vitor Lopes ◽  
Nelson Rocha ◽  
Carlos Lopes ◽  
...  

Whipple disease (WD) is a rare systemic infection caused by Tropheryma whippelii. Neurological involvement has been recognised in 40% of patients, either as initial manifestations or during the course of the disease. We report on a 45 years-old man with WD with initial, persistent and irresistible episodes of daytime somnolence. The patient was HLA-DQB1*0602 positive (genetic marker for narcolepsy). WD diagnosis was suspected on clinical and MRI basis and confirmed by histological and immunohistochemical study of duodenal biopsy. Forty months later all clinical features improved, narcoleptic-like episodes disappeared and cerebral MRI and CSF normalised. Longitudinal neurophysiological studies revealed persistent sleep pattern abnormalities with sleep fragmentation, paucity of slow wave and of REM sleep. The disruption of the hypocretin circuitry in the hypothalamic - diencephalic region triggered by the infection was the probable cause of the hypersomnia and narcopleptic symptoms. WD should be added to the list of causes of secondary hypersomnia.


2005 ◽  
Vol 13 (3) ◽  
pp. 146-148
Author(s):  
Ram Y. Gordon ◽  
Min Sohn ◽  
Susan C. Brozena ◽  
Emily A. Blumberg

2003 ◽  
Vol 139 (12) ◽  
pp. 1046 ◽  
Author(s):  
Michel Drancourt ◽  
Didier Raoult ◽  
Hubert Lpidi ◽  
Florence Fnollar ◽  
Marie-Laure Birg ◽  
...  

2003 ◽  
Vol 47 (2) ◽  
pp. 170-173 ◽  
Author(s):  
David C. Richardson ◽  
Lori L. Burrows ◽  
Bryan Korithoski ◽  
Irving E. Salit ◽  
Jagdish Butany ◽  
...  

2001 ◽  
Vol 39 (7) ◽  
pp. 2425-2430 ◽  
Author(s):  
M. Drancourt ◽  
A. Carlioz ◽  
D. Raoult

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