acute anoxia
Recently Published Documents


TOTAL DOCUMENTS

67
(FIVE YEARS 0)

H-INDEX

17
(FIVE YEARS 0)

2017 ◽  
Vol 13 (12) ◽  
pp. 20170545 ◽  
Author(s):  
Aaron N. Ilacqua ◽  
Alexia M. Kirby ◽  
Matthew E. Pamenter

Naked mole rats (NMRs) are among the most hypoxia-tolerant mammals. Other species respond to hypoxia by either escaping the hypoxic environment or drastically decreasing behavioural activity and body temperature ( T b ) to conserve energy. However, NMRs rarely leave their underground burrows, which are putatively hypoxic and thermally stable near the NMRs' preferred T b . Therefore, we asked whether NMRs are able to employ behavioural and thermoregulatory strategies in response to hypoxia despite their need to remain active and the minimal thermal scope in their burrows. We exposed NMRs to progressively deeper levels of hypoxia (from 21 to 0% O 2 ) while measuring their behaviour and T b . Behavioural activity decreased 40–60% in hypoxia and T b decreased slightly in moderate hypoxia (5–9%) and then further with deeper hypoxia (3% O 2 ). However, even at 3% O 2 NMRs remained somewhat active and warm, and continued to explore their environment. Remarkably, NMRs were active for greater than 90 s in acute anoxia and T b and metabolic rate decreased rapidly. We conclude that NMRs are adapted to remain awake and functional even at the extremes of their hypoxia-tolerance. This adaptation likely reflects variable and challenging levels of environmental hypoxia in the natural habitat of this species.


2013 ◽  
Vol 35 (5) ◽  
pp. 559-568 ◽  
Author(s):  
Hernâni Gonçalves ◽  
Tiago Henriques-Coelho ◽  
Ana Paula Rocha ◽  
André P. Lourenço ◽  
Adelino Leite-Moreira ◽  
...  

2009 ◽  
Vol 15 (4) ◽  
pp. 387-394 ◽  
Author(s):  
Li-Ying Wu ◽  
Zi-Min Ma ◽  
Xue-Lai Fan ◽  
Tong Zhao ◽  
Zhao-Hui Liu ◽  
...  

2008 ◽  
Vol 29 (9) ◽  
pp. 1133-1143 ◽  
Author(s):  
Hernâni Gonçalves ◽  
Tiago Henriques-Coelho ◽  
João Bernardes ◽  
Ana Paula Rocha ◽  
Ana Nogueira ◽  
...  

2008 ◽  
Vol 188 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Heinrich F. Bürgers ◽  
Dominik W. Schelshorn ◽  
Wolfgang Wagner ◽  
Wolfgang Kuschinsky ◽  
Martin H. Maurer

2007 ◽  
Vol 29 (3) ◽  
pp. 260-266 ◽  
Author(s):  
He Huang ◽  
Gabriel G. Haddad

For most vertebrates, oxygen is a prerequisite for survival. Although we have previously shown that Drosophila melanogaster is hypoxia tolerant, how this species senses O2 deprivation and how it survives oxygen-limiting conditions are as yet poorly understood. We began to address this question by testing for anoxic responsiveness in Drosophila adult flies following overexpression of existing EP lines. In this screen, we identified Drosophila CG14709 gene as a homolog of the human multidrug resistance protein 4 (MRP4/ABCC4) that is tightly regulated to oxygen. Ubiquitous expression of dMRP4 in adult flies resulted in increased sensitivity to anoxia as they had longer recovery time from anoxic stupor. When exposed to 4% oxygen chronically (throughout its lifespan), constitutive expression of dMRP4 in larvae caused larval lethality due to growth arrest. Mutations of dMRP4 led to a hypersensitive response to acute anoxia in adult flies but had less impact on larval survival under chronic hypoxia compared with dMRP4 overexpression. Selective expression of this gene in neurons, but not in glia or muscles, mirrored the same phenotype as the ubiquitous one. Thus, our data suggest novel roles for MRP in vivo: 1) dMRP4 regulates the sensitivity to acute or chronic O2 deprivation, and 2) dMRP expression in neurons is sufficient to induce the sensitivity to O2 in the whole organism.


2005 ◽  
Vol 94 (5) ◽  
pp. 1225-1234 ◽  
Author(s):  
Rong Liu ◽  
Jin-Jing Pei ◽  
Xiao-Chuan Wang ◽  
Xin-Wen Zhou ◽  
Qing Tian ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document