Finite element simulations of the effects of an extraoral device, RAMPA, on anterosuperior protraction of the maxilla and comparison with gHu-1 intraoral device

ABSTRACT Objectives To investigate the effects of an extraoral device, right-angle maxillary protraction appliance (RAMPA), combined with a semi-rapid maxillary expansion intraoral device (gHu-1) on the anterosuperior protraction of maxillary bone. Materials and Methods The finite element (FE) model included craniofacial bones and all sutures. The linear assumption was assumed for the FE simulations and the material properties of bones and sutures. The gHu-1 was simulated under screw activations equal to Δx = 0.25 and 0.5 mm in the lateral direction with and without RAMPA under a set of external forces {F1 = 2.94, F2 = 1.47, F3 = 4.44} N. Results Displacement contours, nodal displacements of 12 landmarks, and von Mises stresses were compared. Combining RAMPA and gHu-1 (with Δx = 0.25 mm) resulted in changes in the displacement of the front part of the maxilla near the mid-palatal suture from (0.02, −0.1, −0.02) mm to (0.02, 0.3, 0.8) mm. For gHu-1 with Δx = 0.5 mm, the displacement of the same part changed from (0.04, −0.04, −0.2) mm to (0.04, 0.3, 0) mm. Similar trends were found in other locations. Conclusions The findings are in agreement with the previous cephalometric clinical data of an 8-year-old patient and prove the positive effects of RAMPA on the anterosuperior protraction of the maxilla when it is combined with the intraoral device gHu-1. In addition, RAMPA does not interfere with the lateral expansion generated by the intraoral device.

Comparative Analysis of the Reproduction Accuracy of Main Methods for Finding the Mandible Position in the Centric Relation Using Digital Research Method. Comparison between Analog-to-Digital and Digital Methods: A Preliminary Report

Purpose: To compare the aspect of the reproduction accuracy in studied methods of determination of the (CR) of jaws using the digital research methods. The methods used were bilateral manipulation by P.E. Dawson, frontal deprogrammer, leaf gauge, and intraoral device for recording of Gothic arch angle. Methods: To determine the reproduction accuracy of the centric relation of jaws, we examined 5 patients with intact dentition in a prosthetic dentistry clinic (first class in Angle’s system). For each method, 20 registrations of the centric jaw relation were carried out by one operator. The breaks between definitions were 30 minutes. A total of 400 CR recording operations were carried out (400 records of CR). In order to study the reproducibility of CR determination methods, 200 recorded mandible positions were analyzed by means of an analog-to-digital method (a macro kit Canon 650D, Canon 60 mm macro IS USM f2.8, Canon macro ring MR-14 EX and the computer program Adobe Photoshop) to assess the first occlusal contact obtained in the CR of jaws, while the other 200 were analyzed by means of a digital method (the computer program Avantis for 3D modeling, Prime as a laboratory 3D scanner (DOF), and Trios as an intraoral scanner (3Shape)) to assess the spatial position of the mandible in the CR. Statistical analysis was carried out using STATISTICA-10. In all statistical analysis procedures, the critical significance level p was assumed to be 0.05. Results: In the study of the data by means of the computer program Avanti 3D, the reproducibility of the mandible position in the CR reached 0.119 ± 0.012 mm for frontal deprogrammer, 0.225 ± 0.028, p ≤ 0.05 for bilateral manipulation by Dawson P.E., 0.207 ± 0.02, p ≤ 0.05 for leaf gauge, and 0.120 ± 0,013, p ≤ 0.05 using an intraoral device for recording the Gothic arch angle. The analog-to-digital method showed an identical tendency for reproduction of the mandible position. Conclusions: The digital analysis we made using the Avantis 3D program showed, with high confidence, that the maximum reproducibility of the CR position was reached by using our own design frontal deprogrammer and the device for recording Gothic arch angle.

Digital Design of a Universal Rat Intraoral Device for Therapeutic Evaluation of a Topical Formulation against Candida-Associated Denture Stomatitis

ABSTRACT Candida-associated denture stomatitis (DS) is a persistent and chronic oral infection of the denture-bearing palatal mucosa. DS stems from the ability of the fungal opportunistic pathogen Candida albicans to adhere to denture material and invade palatal tissue. Although DS is the most prevalent form of oral candidiasis, there are currently no feasible therapeutic strategies for the prevention of this recurrent condition. We developed a peptide-based antimicrobial bioadhesive formulation specifically designed for oral topical formulation. In this study, we aimed to evaluate the applicability of the novel formulation for the prevention of C. albicans colonization on denture material and development of clinical disease. To that end, using the latest technological advances in dental digital design and three-dimensional (3D) printing, we fabricated an intraoral device for rats with universal fit. The device was successfully installed and used to develop clinical DS. Importantly, by taking a preventative therapeutic approach, we demonstrated the potential clinical utility of the novel formulation as a safe and feasible prophylactic agent against DS.