adenosine nucleosidase
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2020 ◽  
pp. 247255522097091
Author(s):  
Idris Arslan ◽  
Hafize Akgul ◽  
Murat Kara

Saporin, a type I ribosome-inactivating protein from soapwort plant, is a potent protein synthesis inhibitor. Catalytically, saporin is a characteristic N-glycosidase, and it depurinates a specific adenine residue from a universally conserved loop of the major ribosomal RNA (rRNA) of eukaryotic cells. It is well-known that saporin induces apoptosis through different pathways, including ribotoxic stress response, cell signal transduction, genomic DNA fragmentation and RNA abasic lyase (RAlyase) activity, and NAD+ depletion by poly-(ADP)-ribose polymerase hyperactivation. Saporin’s high enzymatic activity, high stability, and resistance to conjugation procedures make it a well-suited tool for immunotherapy approaches. In the present study, we focus on saporin-based targeted toxins that may be efficacious therapeutic agents for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our discussed points suggest that saporin may be a strategic molecule for therapeutic knockout treatments and a powerful candidate for novel drugs in the struggle against coronavirus 2019 (COVID-19).


2008 ◽  
Vol 49 (11) ◽  
pp. 1765-1765
Author(s):  
D. Riewe ◽  
L. Grosman ◽  
A. R. Fernie ◽  
H. Zauber ◽  
C. Wucke ◽  
...  

2008 ◽  
Vol 49 (10) ◽  
pp. 1572-1579 ◽  
Author(s):  
David Riewe ◽  
Lukasz Grosman ◽  
Alisdair R. Fernie ◽  
Henrik Zauber ◽  
Cornelia Wucke ◽  
...  

2006 ◽  
Vol 67 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Carl Bates ◽  
Zachariah Kendrick ◽  
Nancy McDonald ◽  
Paul C. Kline

2005 ◽  
Vol 66 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Alexandre Campos ◽  
Maria J. Rijo-Johansen ◽  
Maria F. Carneiro ◽  
Pedro Fevereiro

Plant Science ◽  
2000 ◽  
Vol 153 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Ekram Abusamhadneh ◽  
Nancy E McDonald ◽  
Paul C Kline

1991 ◽  
pp. 595-599
Author(s):  
Dietmar Schomburg ◽  
Margit Salzmann

1984 ◽  
Vol 54 (6) ◽  
pp. 847-849 ◽  
Author(s):  
D. LESZCZYNSKA ◽  
Z. SCHNEIDER ◽  
M. TOMASZEWSKI ◽  
M. MAĆKOWIAK

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