Data-driven optimization algorithm for economic operation of microgrid based on dynamic Kriging model and two-stage search strategy

The economic operation optimization of microgrid is an important research topic in the power system. Therefore, this paper proposes a surrogate model particle swarm optimization algorithm based on the global-local search mechanism. Firstly, aiming at the problem that the statistical information of Kriging model is difficult to guarantee the prediction accuracy, the dynamic transformation is carried out to enhance the robustness of the model; secondly, the global-local search mechanism is introduced to make the algorithm fully explore the fitness landscape near the Kriging model after quickly locating the current optimal particle position, so as to achieve the balance of convergence quality and convergence efficiency. The proposed method has been tested on numerous benchmark test functions from two test suites, and the results show that the proposed algorithm has more advantages than other comparison algorithms in optimization accuracy. Finally, simulations are carried out in two operating modes of microgrid islanding and grid-connected, which has verified the effectiveness of the proposed method.

mAb Production Modeling and Design Space Evaluation Including Glycosylation Process

Due to high demand, monoclonal antibodies (mAbs) production needs to be efficient, as well as maintaining a high product quality. Quality by design (QbD) via predictive process modeling greatly facilitates process understanding and can be used to adjust process parameters to further improve the unit operations. In this work, mechanistic and dynamic kriging models are developed to capture the protein productivity and glycan fractions under different temperatures and pH levels. The design of experiments is used to generate input and output data for model training. The dynamic kriging model shows good performance in capturing the dynamic profiles of cell cultures and glycosylation using only limited input data. The developed model is further used for feasibility analysis, and successfully identifies the operating design space, maintaining high productivity and guaranteed product quality.

Framework of Reliability-Based Stochastic Mobility Map for Next Generation NATO Reference Mobility Model

A framework for generation of reliability-based stochastic off-road mobility maps is developed to support the next generation NATO reference mobility model (NG-NRMM) using full stochastic knowledge of terrain properties and modern complex terramechanics modeling and simulation capabilities. The framework is for carrying out uncertainty quantification (UQ) and reliability assessment for Speed Made Good and GO/NOGO decisions for the ground vehicle based on the input variability models of the terrain elevation and soil property parameters. To generate the distribution of the slope at given point, realizations of the elevation raster are generated using the normal distribution. For the soil property parameters, such as cohesion, friction, and bulk density, the min and max values obtained from geotechnical databases for each of the soil types are used to generate the normal distribution with a 99% confidence value range. In the framework, the ranges of terramechanics input parameters that will cover the regions of interest are first identified. Within these ranges of input parameters, a dynamic kriging (DKG) surrogate model is obtained for the maximum speed of the nevada automotive test center (NATC) wheeled vehicle platform complex terramechanics model. Finally, inverse reliability analysis using Monte Carlo simulation is carried out to generate the reliability-based stochastic mobility maps for Speed Made Good and GO/NOGO decisions. It is found that the deterministic map of the region of interest has probability of only 25% to achieve the indicated speed.