Inclusive bottom hadron decays are analyzed based on the heavy quark effective field theory (HQEFT). Special attentions in this paper are paid to the b→u transitions and nonspectator effects. As a consequence, the CKM quark mixing matrix elements |Vub| and |Vcb| are reliably extracted from the inclusive semileptonic decays B→Xueν and B→Xceν. Various observables, such as the semileptonic branch ratio BSL, the lifetime differences among B-, B0, Bsand Λbhadrons, the charm counting nc, are predicted and found to be consistent with the present experimental data.