Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment

Octacalcium phosphate (OCP, Ca8H2(PO4)6·5H2O) is known to be a possible precursor of biological hydroxyapatite formation of organic bone tissue. OCP has higher biocompatibility and osseointegration rate compared to other calcium phosphates. In this work, the synthesis of low-temperature calcium phosphate compounds and substituted forms of those at physiological temperatures is shown. Strontium is used to improve bioactive properties of the material. Strontium was inserted into the OCP structure by ionic substitution in solutions. The processes of phase formation of low-temperature OCP with theoretical substitution of strontium for calcium up to 50 at.% in conditions close to physiological, i.e., temperature 35–37 °C and normal pressure, were described. The effect of strontium substitution range on changes in the crystal lattice of materials, the microstructural features, surface morphology and biological properties in vitro has been established. The results of the study indicate the effectiveness of using strontium in OCP for improving biocompatibility of OCP based composite materials intended for bone repair.

Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications

Hydroxyapatite (HAP) has been the gold standard in the biomedical field due to its composition and similarity to human bone. Properties such as shape, size, morphology, and ionic substitution can be tailored through the use of different synthesis techniques and compounds. Regardless of the ability to determine its physicochemical properties, a conclusion for the correlation with the biological response it is yet to be found. Hence, a special focus on the most desirable properties for an appropriate biological response needs to be addressed. This review provides an overview of the fundamental properties of hydroxyapatite nanoparticles and the characterization of physicochemical properties involved in their biological response and role as a drug delivery system. A summary of the main chemical properties and applications of hydroxyapatite, the advantages of using nanoparticles, and the influence of shape, size, functional group, morphology, and crystalline phase in the biological response is presented. A special emphasis was placed on the analysis of chemical and physical interactions of the nanoparticles and the cargo, which was explained through the use of spectroscopic and physical techniques such as FTIR, Raman, XRD, SEM, DLS, and BET. We discuss the properties tailored for hydroxyapatite nanoparticles for a specific biomolecule based on the compilation of studies performed on proteins, peptides, drugs, and genetic material.

Defining the Structural Stability Field of Disordered Fluorite Oxides

Fluorite-structured oxides constitute an important class of materials for energy technologies. Despite their high level of structural symmetry and simplicity, these materials can accommodate atomic disorder without losing crystallinity, making them indispensable for uses in environments with high temperature, changing chemical compositions, or intense radiation fields. In this contribution, we present a set of simple rules that predict whether a compound may adopt a disordered fluorite structure. This approach is closely aligned with Pauling’s rules for ionic crystal structures and Goldschmidt’s rules for ionic substitution.

Oxidation of cyclohexene with hydrogen peroxide over nano-crystalline MnxCe1−xO2−δ catalyst

The liquid-phase catalytic oxidation of cyclohexene to produce cyclohexenol and cyclohexenone directly was attempted using Mn ion substituted in ceria in acetonitrile solvent with 30% H2O2 as oxidant under atmospheric pressure. Structural studies by XRD show indication of ionically dispersed metal over ceria. Among all the catalysts studied, the Mn0.05Ce0.95O2−δ catalyst prepared by the solution combustion method has shown more activity (95.3% conversion with 98.7% selectivity) than others. The influences of the amount of Mn loading, temperature, time, the concentration of H2O2 and solvent have also been investigated. The enhancement of activity in Mn2+ ion substituted ceria as compared to other catalysts has been attributed to Mn–O–Ce ionic interaction in the combustion synthesized catalyst. Ionic substitution also helps to get an active stable catalyst with lower risk of Mn-leaching compared to the impregnated catalyst.