Treatment Compliance of Multidrug Resistant Tuberculosis in Uzbekistan: Does Practice Follow Policy?

Compliance with treatment guidelines is essential to achieve successful outcomes in tuberculosis patients. Thus, we assessed if multidrug-resistant tuberculosis treatment practices from 2012–2018 in Uzbekistan were compliant with national guidelines in terms of regimens prescribed, weight-based drug dosages used, and documentation of treatment changes (such as prolongation of intensive phase, change of drugs, and their reasons) in the treatment card and Consilium form. A total of 1481 patients were included. Of them, only 25% received standardized regimens as per guidelines and the remaining received individualized regimens. There was an increasing trend in using standardized regimens from 2% in 2012 to 44% in 2018. Compliance to recommended weight-based drug dosages was observed in 85% of the patients during the intensive phase and 84% in the continuation phase—ranged 71–91% over the years. Prolongation of the intensive phase was done in 42% of patients. The treatment was changed in 44% of patients during the intensive phase and 34% of patients during the continuation phase. The documentation of treatment changes was suboptimal (42–75%) during the initial years (2012–2014); however, it improved significantly during later years (86–100%). Future research should explore reasons for non-compliance so that the quality of patient care can be improved.

Mathematical Formulae That Validate The Germ Terrain Duality Theory; The Comparative Size of The Immanent Cellular Dust [Microzymas]

Drug dosages, whether calculated via the ratio (rainbow), proportion, formulae or dimensional analysis method are determined by various factors. These factors include the weight of the patient and the route of administration. Both weight and route of drug administration are terrainrelated parameters.

Mathematical Formulae That Validate the Germ Terrain Duality Theory; The Comparative Size of the Immanent Cellular Dust [Microzymas]

Drug dosages, whether calculated via the ratio (rainbow), proportion, formulae or dimensional analysis method are determined by various factors. These factors include the weight of the patient and the route of administration. Both weight and route of drug administration are terrain related parameters.

Emergencies in Anaesthesia

The updated third edition of Emergencies in Anaesthesia serves as a guide to all emergency situations encountered during, and immediately following, anaesthesia. Re-structured to follow the ABCDE emergency approach, this handbook guides the clinician through what to do and when, in a format designed for rapid use. In each chapter, topics are ordered alphabetically and management is presented in a checklist format. Symbols are used to indicate clinical severity ranging from life-threatening to minor, and the book includes drug dosages, infusion regimes, and key algorithms for quick reference. This third edition also includes new frameworks for emergency management and new material on human factors.