On the interrelation between alcohol addiction–like behaviors in rats

Rationale Alcohol use disorder (AUD) is a complex, heterogeneous disorder that only occurs in a minority of alcohol users. Various behavioral constructs, including excessive intake, habit formation, motivation for alcohol and resistance to punishment have been implicated in AUD, but their interrelatedness is unclear. Objective The aim of this study was therefore to explore the relation between these AUD-associated behavioral constructs in rats. We hypothesised that a subpopulation of animals could be identified that, based on these measures, display consistent AUD-like behavior. Methods Lister Hooded rats (n = 47) were characterised for alcohol consumption, habit formation, motivation for alcohol and quinine-adulterated alcohol consumption. The interrelation between these measures was evaluated through correlation and cluster analyses. In addition, addiction severity scores were computed using different combinations of the behavioral measures, to assess the consistency of the AUD-like subpopulation. Results We found that the data was uniformly distributed, as there was no significant tendency of the behavioral measures to cluster in the dataset. On the basis of multiple ranked addiction severity scores, five animals (~ 11%) were classified as displaying AUD-like behavior. The composition of the remaining subpopulation of animals with the highest addiction severity score (9 rats; ~ 19%) varied, depending on the combination of measures included. Conclusion Consistent AUD-like behavior was detected in a small proportion of alcohol drinking rats. Alcohol consumption, habit formation, motivation for alcohol and punishment resistance contribute in varying degrees to the AUD-like phenotype across the population. These findings emphasise the importance of considering the heterogeneity of AUD-like behavior.

Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms

There has been a fundamental failure to translate preclinically supported research into clinically efficacious treatments for psychiatric disorders. One of the greatest impediments toward improving this species gap has been the difficulty of identifying translatable neurophysiological signals that are related to specific behavioral constructs. Here, we present evidence from three paradigms that were completed by humans and mice using analogous procedures, with each task eliciting candidate a priori defined electrophysiological signals underlying effortful motivation, reinforcement learning, and cognitive control. The effortful motivation was assessed using a progressive ratio breakpoint task, yielding a similar decrease in alpha-band activity over time in both species. Reinforcement learning was assessed via feedback in a probabilistic learning task with delta power significantly modulated by reward surprise in both species. Additionally, cognitive control was assessed in the five-choice continuous performance task, yielding response-locked theta power seen across species, and modulated by difficulty in humans. Together, these successes, and also the teachings from these failures, provide a roadmap towards the use of electrophysiology as a method for translating findings from the preclinical assays to the clinical settings.

A common limiter circuit for opioid choice and relapse identified in a rodent addiction model

Activity in numerous brain regions drives heroin seeking, but no circuits that limit heroin seeking have been identified. Furthermore, the neural circuits controlling opioid choice are unknown. In this study, we examined the role of the infralimbic cortex (IL) to nucleus accumbens shell (NAshell) pathway during heroin choice and relapse. This model yielded subpopulations of heroin versus food preferring rats during choice, and choice was unrelated to subsequent relapse rates to heroin versus food cues, suggesting that choice and relapse are distinct behavioral constructs. Supporting this, inactivation of the IL with muscimol produced differential effects on opioid choice versus relapse. A pathway-specific chemogenetic approach revealed, however, that the IL-NAshell pathway acts as a common limiter of opioid choice and relapse. Furthermore, dendritic spines in IL-NAshell neurons encode distinct aspects of heroin versus food reinforcement. Thus, opioid choice and relapse share a common addiction-limiting circuit in the IL-NAshell pathway.

Ghrelin and Glucagon-Like Peptide-1: A Gut-Brain Axis Battle for Food Reward

Eating behaviors are influenced by the reinforcing properties of foods that can favor decisions driven by reward incentives over metabolic needs. These food reward-motivated behaviors are modulated by gut-derived peptides such as ghrelin and glucagon-like peptide-1 (GLP-1) that are well-established to promote or reduce energy intake, respectively. In this review we highlight the antagonizing actions of ghrelin and GLP-1 on various behavioral constructs related to food reward/reinforcement, including reactivity to food cues, conditioned meal anticipation, effort-based food-motivated behaviors, and flavor-nutrient preference and aversion learning. We integrate physiological and behavioral neuroscience studies conducted in both rodents and human to illustrate translational findings of interest for the treatment of obesity or metabolic impairments. Collectively, the literature discussed herein highlights a model where ghrelin and GLP-1 regulate food reward-motivated behaviors via both competing and independent neurobiological and behavioral mechanisms.

Behavioral Correlates of GPS Device Usage Among Small-Scale Fishers in Malaysia

This article aims to examine the relationship between selected behavioral factors and Global Positioning System (GPS) usage among small-scale fishers in Malaysia. An adapted version of the Unified Theory of Acceptance and Use of Technology (UTAUT) was tested among a sample of 400 small-scale fishers to examine the relationship between technology-related behavioral constructs (compatibility, social influence, effort expectancy, learning culture, and performance expectancy) and GPS usage. The sample was selected from 12 fishery districts in Malaysia. Confirmatory factor analysis (CFA) confirmed that all five technology-related behavioral constructs included in the model recorded a significant relationship with GPS usage. The results extend the generalizability of the UTAUT to a previously understudied setting of community technology usage. Understanding GPS usage among small-scale fishers from the extended UTAUT perspective can provide policy makers, public, nongovernmental organizations (NGOs), and other concerned parties with knowledge that can build awareness and shape capacity building efforts for small-scale interventions to increase the use of GPS. This will, in turn, reduce the risks associated with fishing routines and enhance fishing yields.

IDENTIFYING BEHAVIORAL CONSTRUCTS IN RELATION TO USER CYBERSECURITY BEHAVIOR

A behavior such as enabling two factor authentication has a positive impact on a users’ information security. It is assumed that given the benefits, users will want to perform this cybersecurity related behavior. However, some users choose not to perform the beneficial security behavior. Varied explanations have been provided as to why users choose to perform or not perform cybersecurity behaviors. The factors that influence users in the decision making of whether to perform or not perform a cybersecurity related behavior are referred to as constructs. This study seeks to combine the results of selected studied, with the aim of identifying prominent user cybersecurity behavior constructs, as well as the relationships between the constructs. The contributions made by the study is the consolidated visualization of behavior constructs that have an influence on user cybersecurity behavior. Furthermore, the study also provides practical applications of the cybersecurity behavior constructs. To achieve the goals of the study, a literature review is used as the study methodology. Data from previous studies is systematically collected, and analyzed. The study makes use of the Theoretical Domains Theory as a tool, which aids in consolidating the different behavior constructs found in cybersecurity literature. The constructs Beliefs about Capabilities, Beliefs about Consequences, Reinforcements, Social Influences, Intentions, Emotions, Social/Professional Role and Identity, Knowledge and Skills are found to have influence on cybersecurity behavior.

Validated Assessment of Schoolchildren’s Attitude Towards Basic Life Support and Automated External Defibrillator Use

As knowledge and attitude towards performing basic life support and using an automated external defibrillator (BLS and AED) contribute equally to improving survival after out-of-hospital cardiac arrest, we aimed to develop a measuring instrument for a validated assessment of schoolchildrens' attitude towards BLS and AED. The objective was to identify, measure, and address pertinent attitude dimensions that influence the intention to actually perform BLS and AED. We conducted a BLS and AED course for seventh and ninth grade students. Students fulfilled pre- and post-course questionnaires on attitude and intention to perform BLS and AED. The measuring instrument was developed with the use of exploratory factor analysis with application of principal component analysis and confirmatory factor analysis with application of structural equation modeling. Measurement invariance across different groups (gender, grades, previous courses) was tested with Wilcoxon signed ranks test and Mann–Whitney U test. Differences in attitude pre- and post-course were evaluated by application of Mann–Whitney U test. The final attitude model consisted of 3 behavioral constructs (self-confidence, positive motivation, and amotivation). Self-confidence was the major construct directly affecting the intention to act. Positive motivation had a negligible direct effect on intention but correlated strongly with self-confidence. The effect of attitude on the intention to help is therefore less complicated than was expected, which relieves the non-professional educators of having to know the specifics of the different behavioral constructs.

Identification of Six Emergent Types Based on Cognitive and Affective Constructs that Explain Individuals’ Relationship with the Biosphere

To address the pathological human–nature nexus, psychological processes that impact this relationship need to be further understood. Individual differences related to personality, values, worldviews, affect, and beliefs are likely to influence how people relate to the natural world. However, there is a lack of empirically-based ecopsychological research exploring multiple individual attributes. Understanding individual differences enables the strategic design of planetary-focused interventions, such as advocacy, policy, and technology development. Using a theoretical model that incorporates intrinsic, affective, cognitive, and behavioral constructs, this study sought to identify and describe different types of people and their relationship with the biosphere. Seven hundred and fifty-three people completed an online quantitative questionnaire battery. Results from the cluster analyses of the cognitive and affective constructs showed that six heterogeneous types existed. Their different descriptive expressions of intrinsic, affective, cognitive, and behavioral constructs provide a deeper understanding of each type’s relationship with the biosphere.

Cognitive, Affective, and Behavioral Constructs of COVID-19 Health Beliefs: A Comparison Between Sexual Minority and Heterosexual Individuals in Taiwan

This online survey study aimed to compare the cognitive, affective, and behavioral constructs of health beliefs related to coronavirus disease 2019 (COVID-19) between sexual minority and heterosexual individuals in Taiwan. In total, 533 sexual minority and 1421 heterosexual participants were recruited through a Facebook advertisement. The constructs pertaining to cognition (perceived relative susceptibility to COVID-19, perceived COVID-19 severity, having sufficient knowledge and information on COVID-19, and confidence in coping with COVID-19), affect (worry toward COVID-19), and behavior (adoption of health-protective behaviors) in relation to health beliefs about COVID-19 were compared between sexual minority and heterosexual participants. The results indicated that sexual minority participants had lower perceived susceptibility to COVID-19, greater self-confidence in coping with COVID-19, and lower worry about COVID-19 and were less likely to maintain good indoor ventilation and disinfect their household than heterosexual individuals. Sexual orientation is the modifying factor for the Health Belief Model in the COVID-19 pandemic and should be taken into consideration when medical professionals establish prevention programs for COVID-19.