Exploring the whole standard operating procedure for phage therapy in clinical practice

We have entered the post-antibiotic era. Phage therapy has recently been given renewed attention because bacteriophages are easily available and can kill bacteria. Many reports have demonstrated successful phage treatment of bacterial infection, whereas some studies have shown that phage therapy is not as effective as expected. In general, establishment of a standard operating procedure will ensure the success of phage therapy. In this paper, the whole operating procedure for phage therapy in clinical practice is explored and analyzed to comprehensively understand the success of using phage for the treatment of bacterial infectious disease in the future. The procedure includes the following: enrollment of patients for phage therapy; establishment of phage libraries; pathogenic bacterial isolation and identification; screening for effective phages against pathogenic bacteria; phage formulation preparation; phage preparation administration strategy and route; monitoring the efficacy of phage therapy; and detection of the emergence of phage-resistant strains. Finally, we outline the whole standard operating procedure for phage therapy in clinical practice. It is believed that phage therapy will be used successfully, especially in personalized medicine for the treatment of bacterial infectious diseases. Hopefully, this procedure will provide support for the entry of phage therapy into the clinic as soon as possible.

A Study on Cyber Security Threats in a Shipboard Integrated Navigational System

The integrated navigational system (INS) enhances the effectiveness and safety of ship navigation by providing multifunctional display on the basis of integration of at least two navigational functions, the voyage route monitoring with Electronic Chart Display and Information System (ECDIS) and collision avoidance with radar. The INS is essentially a software platform for fusion of data from the major ECDIS and radar systems with sensors for the additional navigation functions of route planning, status and data display, and alert management. This paper presents a study on cyber security resilience examination of a shipboard INS installed on a RoPax ship engaged in international trade. The study was based on a mixed-method approach, combining an interview of the ship's navigational ranks and cyber security testing of the INS using an industry vulnerability scanner. The identified threats were analyzed qualitatively to study the source of cyber risks threatening the INS. The results obtained point out cyber threats related to weaknesses of the INS underlying operating system, suggesting a need for occasional preventive maintenance in addition to the regulatory compliance required.

Design of GPS-Based Intelligent Logistics Management System

The GPS system is in order to the logistics and transport process. Customers through the GPS system can real-time understanding of the goods in transit, and projections to reach the destination time. GPS can provide the vehicle location, security, anti-robbery, driving the route monitoring and call conductor. To achieve all of the above features must have the three elements of the GPS terminal, transmission network and monitoring platform. Intelligent logistics management system goal is precisely for large and medium-sized logistics enterprises a set of functional, practical and intelligent logistics solutions for the rapid response capability. The paper puts forward the design of GPS-based intelligent logistics management system.