Stereodivergent entry to β-branched β-trifluoromethyl α-amino acid derivatives by sequential catalytic asymmetric reactions

Currently, conventional reductive catalytic methodologies do not guarantee general access to enantioenriched β-branched β-trifluoromethyl α-amino acid derivatives. Herein, a one-pot approach to these important α-amino acids, grounded on the reduction...

Copper-catalyzed asymmetric cyclization of alkenyl diynes: method development and new mechanistic insights

Metal carbenes have proven to be one of the most important and useful intermediates in organic synthesis, but catalytic asymmetric reactions involving metal carbenes are still scarce and remain a...

Conjugated ynones in catalytic enantioselective reactions

This review summarizes the recent literature examples of catalytic asymmetric reactions of conjugated ynones and classified these reaction types, alongside their mechanistic insights whenever possible.