Regiocontrolled Synthesis of Enantioenriched 2-Substituted Dehydropiperidines by Stereospecific Allyl Allyl Cross-Coupling of a Chiral Allylic Boronate

The palladium-catalyzed cross-coupling of an optically enriched dehydropiperidinyl boronate with cinnamyl carbonates was optimized to minimize stereochemical erosion. Although the coupling of two unsymmetrical allyl fragments may generate four possible...

Regiocontrolled synthesis of 2,4,6-triarylpyridines from methyl ketones, electron-deficient acetylenes and ammonium acetate

A simple method to access unsymmetrical 2,4,6-triarylpyridines starting from available methyl ketones and electron-deficient acetylenes was developed.

Recent advances in the synthesis of imidazoles

The review highlights the recent advances (2018-present) in the regiocontrolled synthesis of substituted imidazoles.

Regiocontrolled Synthesis of 6,7-Dihydro-4H-pyrazolo[5,1-c][1,4]oxazines

Synthetic access to 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazines has been achieved in 3–4 steps from commercially available pyrazoles. Optimization of a protected hydroxyethyl group on N1 enabled the regiocontrolled construction of pyrazole-5-aldehydes in high yields; subsequent deprotection and reduction generated fused heterocyclic scaffolds bearing multiple substitution patterns. Moreover, the intermediate pyrazole lactols were shown to be versatile synthetic building blocks.