Comparative study of thiopentone sodium, propofol, etomidate for anesthetic efficacy & effect on seizure duration in electroconvulsive therapy

Electroconvulsive treatment (ECT) is an entrenched mental treatment where seizures are electrically actuated in patients for restorative impacts. ECT can deliver extreme unsettling influences in the cardiovascular framework most generally a transient time of hypertension & changes in the pulse and a stamped increment in cerebral blood stream and intracranial weight. These hemodynamics changes might be adjusted utilizing different sedative medications. This investigation was attempted to think about the impacts of propofol, etomidate and thiopentone sodium utilized as IV sedative operators in changed ECT as respects, acceptance time & nature of sedation, adjustment of hemodynamics, seizure length & recuperation time.After authorization acquired from the moral board of trustees for the investigation, composed assent from the patient & family members was taken. This investigation was led in the division of anesthesiology at Civil Hospital, Ahmedabad, which remembered a sum of 90 patients for the 18-60 years age gathering.In our current investigation, we inferred that each of the three instigating operators had sure more than each other when the examination boundaries were individualized. Propofol had the upside of stable hemodynamic boundaries, smooth enlistment & fast recuperation in contrast with etomidate & thiopentone. Nonetheless, it was related with more limited span of seizure. The benefit of thiopentone sodium of having longer seizure length than propofol of having longer seizure span was brought about at the expense of a generally delayed recuperation period. The clear bit of leeway of a more extended seizure length with etomidate could be utilized for better clinical adequacy. Notwithstanding, it was related with myoclonic jerks during the cycle of acceptance. Further examinations ought to be planned to utilize a stage & mix of medications with the goal that the most ideal impacts of each medication can be sensibly utilized.

T

This chapter presents information on neonatal drugs that begin with T, including use, pharmacology, adverse effects, fetal and infant implications of maternal treatment, treatment, and supply of Teicoplanin, Tenofovir, Tetracaine = Amethocaine (former BAN), Tetracosactide = Tetracosactrin (former BAN), Tetracycline, Thiopental sodium = Thiopentone sodium (former BAN), Tobramycin, Topiramate, Tramadol, Tranexamic acid, Trimethoprim, and Trometamol = Tromethamine (USAN)

A Comparative Study of Smooth Insertion of Laryngeal Mask Airway with Propofol and Thiopentone Combined with Midazolam

Background: Successful insertion of Laryngeal Mask Airway (LMA) requires sufficient depth of anesthesia and depression of airway reflexes to avoid gagging, coughing and laryngeal spasm. The LMA is popular because it is easy to insert and it provides a secure airway for the patients who breathe spontaneously. Indeed, the intravent LMA instruction manual specifically recommends propofol for induction of anesthesia during LMA insertion. As a matter of fact Propofol and LMA insertion has become synonymous. However, there are some problems related to the use of propofol, for example, relatively high cost. This observational study was conducted to compare efficacy and safety of propofol and thiopentone -midazolam in smooth insertion of LMA and the hemodynamic changes over time in both groups. Methods: The study was done in the Department of Anesthesiology, Chittagong Medical College from July, 2012 to December, 2013. All the patients scheduled for elective surgical procedures under general anesthesia fulfilling the inclusion criteria, were the study population. Data was analyzed by computer based software SPSS-21. Results: Overall LMA insertion condition was improved better by the use of midazolam with thiopentone sodium (Group B) than propofol (Group A). The drug regime used in group A (Propofol) was expensive than group B (midazolam with thiopentone sodium) with indifferent hemodynamic stability in both groups. Mean ages of patients were 32.43 years ± SD- 10.67 years in group A and 33.5 years ± SD- 10.63 years in group B. Conclusion: In the perspective of our study, for smooth insertion of LMA midazolam-thiopentone sodium regime is cheaper and can be effectively and safely used over propofol regime. Chatt Maa Shi Hosp Med Coll J; Vol.17 (1); Jan 2018; Page 38-41