New biocompatible hydroxy double salts and their drug delivery properties

Two novel biocompatible hydroxy double salts (HDSs) have been synthesised, loaded with the drug naproxen, and formulated into tablets.

Gd(iii) complexes intercalated into hydroxy double salts as potential MRI contrast agents

Chelated Gd3+complexes were loaded into hydroxy double salts and found to retain their proton relaxivity properties after intercalation.

Controlled Release Kinetics in Hydroxy Double Salts: Effect of Host Anion Structure

Nanodimensional layered metal hydroxides such as layered double hydroxides (LDHs) and hydroxy double salts (HDSs) can undergo anion exchange reactions releasing intercalated anions. Because of this, these metal hydroxides have found applications in controlled release delivery of bioactive species such as drugs and pesticides. In this work, isomers of hydroxycinnamate were used as model compounds to systematically explore the effects of anion structure on the rate and extent of anion release in HDSs. Following intercalation and subsequent release of the isomers, it has been demonstrated that the nature and position of substituent groups on intercalated anions have profound effects on the rate and extent of release. The extent of release was correlated with the magnitude of dipole moments while the rate of reaction showed strong dependence on the extent of hydrogen bonding within the layers. The orthoisomer showed a more sustained and complete release as compared to the other isomers.