sarain a
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Author(s):  
Xiu‐Ning Hu ◽  
Dong‐Ping Wu ◽  
Ye‐Peng Xu ◽  
Pei‐Qiang Huang

2018 ◽  
Vol 20 (21) ◽  
pp. 6701-6704 ◽  
Author(s):  
Yu Wang ◽  
Lingying Leng ◽  
Ying Liu ◽  
Guiying Dai ◽  
Fanglin Xue ◽  
...  

2018 ◽  
Vol 140 (15) ◽  
pp. 5319-5319 ◽  
Author(s):  
Michael H. Becker ◽  
Peter Chua ◽  
Robert Downham ◽  
Christopher J. Douglas ◽  
Neil K. Garg ◽  
...  
Keyword(s):  

Author(s):  
Douglass F. Taber

(−)-α-Kainic acid 3 is widely used in neuropharmacological studies. En route to 3, Takashi Ohshima of Kyushu University found (Chem. Eur. J. 2015, 21, 3937) that the intramolecular ene cyclization of 1 delivered 2 with high diastereocontrol. Karl A. Scheidt of Northwestern University set (Angew. Chem. Int. Ed. 2015, 54, 6900) the absolute configuration of 5 and so of serpentine 6 by the organocatalyzed cyclization of 4. This is the first total synthesis of that alkaloid. Yanxing Jia of Peking University prepared (Angew. Chem. Int. Ed. 2015, 54, 6255) the benzofuran 8 by the Pd-mediated cyclization of the alkyne 7. An organo­catalyzed intermolecular Michael addition set the absolute configuration of (−)-galanthamine 9. Liu-Zhu Gong of the University of Science and Technology of China assem­bled (Chem. Eur. J. 2015, 21, 8389) (+)-trigolutes B 13 by the organocatalyzed addition of 10 to 11 to give 12. Barry M. Trost of Stanford University employed (Chem. Sci. 2015, 6, 349) a similar strategy in a synthesis of (−)-perophoramidine (not illustrated). Satoshi Yokoshima and Tohru Fukuyama of Nagoya University showed (Angew. Chem. Int. Ed. 2015, 54, 7367) that on deprotection, 14 was converted to an eight-membered cyclic nitrone, that further cyclized to 15. This set the stage for the synthesis of sarain A 16. Patrick G. Harran of UCLA has extensively studied the complex alkaloid (−)-diazonamide A (not illustrated). Structural simplification and optimization of antimitotic activity led to the macrolactam DZ-2384 18. It is exciting that 18 could be prepared (Angew. Chem. Int. Ed. 2015, 54, 4818) on a multigram scale by selective electrochemical oxidation of the much simpler precursor 17.


2017 ◽  
Vol 58 (43) ◽  
pp. 4122-4124 ◽  
Author(s):  
Jiao Meng ◽  
Yu Wang ◽  
Yong Qin ◽  
Xiao-Yu Liu
Keyword(s):  

2015 ◽  
Vol 127 (25) ◽  
pp. 7475-7478 ◽  
Author(s):  
Takuya Higo ◽  
Tomoya Ukegawa ◽  
Satoshi Yokoshima ◽  
Tohru Fukuyama

2011 ◽  
Vol 17 (36) ◽  
pp. 9907-9910 ◽  
Author(s):  
Sabrina Peixoto ◽  
Marie-Thérèse Martin ◽  
David Crich ◽  
Bernard Delpech ◽  
Christian Marazano
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