The Effect Of Back Massage Therapy On Rheumatic Pain In The Elderly In The Geriatric Clinic Kesdam Cijantung Hospital, East Jakarta Year 2019

Rheumatic disease is a chronic joint inflammatory disease caused by an autoimmune disorder. Pain is a clinical complaint most frequently encountered by nurses. This study aims to determine the comparison of the results of back message therapy and not back message therapy with pain in elderly rheumatism. This study is a quantitative study with a quasi-experimental research design made using a non-equivalent group design with pre and post tests. The research sample was 18 respondents. The sampling technique used purposive sampling. Data collection using experimental method. The instrument for measuring the level of pain uses a numerical rating scale (NRS) . From the results of statistical analysis using the Independent Sample Test, it is known that the average difference in the measurement results of back message therapy in the pre category of 5.22 and post is 2.00 with p value = 0.000 (<0.05), while there is a difference of pre 5, 17 and post 3.50 on no back message therapy which obtained p value = 0.000 (<0.05). It was concluded that there was a significant difference in pain in elderly arthritic patients who took back message therapy and did not follow back message therapy. It is important for the results of this study that health workers teach back message therapy for the elderly who experience pain because this is a very effective therapy for people with rheumatism.Keywords: Back Message, Rheumatic Pain, Elderly

Analisis Natrium Diklofenak Dalam Sampel Jamu Pegal Linu Yang Dijual Di Kabupaten Semarang Secara Klt-Spektrofotometri Uv-Vis

Herbal medicine for rheumatic pain is one of the traditional medicinal products that are massively demanded by the public because it has many benefits. Medicinal Chemicals (MC) are often added to herbal medicine for rheumatic pain to strengthen their properties, one of which is Diclofenac Sodium. Based on the Decree of the Minister of Health of the Republic of Indonesia No. 246 of 2010, traditional medicines are prohibited from containing Medicinal Chemicals (MC). This study aims to analyze the content of Diclofenac Sodium Medicinal Chemicals (MC) in the herbal medicine for rheumatic pain which is sold in Semarang Regency. This type of research was conducted using a laboratory experimental method which descriptively describes the results of the study based on the data obtained. The research method consisted of organoleptic test, qualitative analysis and quantitative analysis of the samples of herbal medicine for aches and pains. Organoleptic test was carried out by tasting the taste, smelling the smell, seeing the color and feeling the dosage form of the Jamu Pegal Linu sample. Qualitative analysis was performed by Thin Layer Chromatography (TLC) and quantitative analysis was performed by UV-Vis Spectrophotometry with 3 samples considered positive. Samples B, D, and E which is sold in Semarang Regency were positive for Diclofenac Sodium based on the Rf values ​​obtained from the samples, namely 0.28, 0.3, and 0.3, which were almost the same as the standard Rf for Sodium Diclofenac, which was 0.26. The stationary phase used a Silica Gel 254 and the mobile phase used Ethyl Acetate and N-Hexane in a ratio of 25: 25. In quantitative analysis, a wavelength of 275 nm was obtained with a linear equation y = 0.0245x + 0.0989 and a value of r = 0.9994 with a concentration of obtained in samples B, D, E were 39.27%, 2.67% and 4.9%, respectively. ABSTRAK Jamu Pegal Linu merupakan salah satu produk obat tradisional yang banyak diminati oleh masyarakat karena memiliki banyak manfaat. Bahan Kimia Obat (BKO) sering ditambahkan pada Jamu Pegal Linu untuk menambah khasiatnya, salah satunya adalah Natrium Diklofenak. Berdasarkan Permenkes RI No. 246 tahun 2010, obat tradisional dilarang mengandung BKO. Penelitian ini bertujuan untuk menganalisis kandungan Natrium Diklofenak pada sediaan Jamu Pegal Linu yang dijual di Kabupaten Semarang. Jenis penelitian dilakukan menggunakan metode eksperimental laboratorium. Metode penelitian terdiri dari uji organoleptis, analisis kualitatif dan kuantitatif. Uji organoleptis dilakukan dengan dengan cara mengamati warna, bau, rasa dan bentuk sampel. Analisis kualitatif dilakukan dengan Kromatografi Lapis Tipis (KLT) dan analisis kuantitatif dilakukan dengan Spektrofotometri UV-Vis. Sampel B, D, dan E yang dijual di Kabupaten Semarang positif mengandung Natrium Diklofenak berdasarkan nilai Rf yang didapatkan dari sampel berturut-turut yaitu 0.28, 0.3, dan 0.3 mendekati nilai Rf baku Natrium Diklfenak yaitu 0.26. Fase diam menggunakan Silica Gel 254 dan fase gerak menggunakan Etil Asetat dan N-Heksan dengan perbandingan 25 : 25. Pada analisis kuantitatif diperoleh panjang gelombang 275 nm dengan persamaan garis linier y = 0,0245x + 0,0989 dan nilai r = 0.9994 dengan kadar pada sampel B, D, E berturut-turut adalah 39.27%, 2.67% dan 4.9%.

Qualitative and Quantitative Analysis of Dexamethasone in Rheumatic Pain Herbal Medicine Using Thin-Layer Chromatography (TLC) – Densitometry

Chemical medicine is chemical substances that is used as the main ingredient of chemical drugs. This compound is usually added to herbal medicine preparation to strengthen the indication of the traditional medicine.Chemical medicine was prohibited from being added to traditional medicinal preparations. But in reality, a lot of medicinal herbs could have contained medicinal chemicals on the market sale. This purpose of this research was to know the chemical contamination of the dexamethasone also the concentration contained in the rheumatic pain herbal medicine. This research was used three kind of rheumatic pain herbal medicine sample to identify dexamethasone, the sample code is S1, S2, and S3. The analysis of qualitative method are organoleptic test, FTIR characteristic test, TLC evaluation. The analysis of quantitative were purposed to know the dexamethasone concentration contained on the rheumatic pain herbal medicine using TLC-Densitometric method. The result show that the three sample of rheumathic pain herbal medicine were contaminated by dexamethasone chemical medicine. Based on organoleptic test, the results show color, smell, and taste. Characterization of the dexamethasone using FTIR were to know functional groups of dexamethasone contained in the rheumatic pain herbal medicine sample, the functional groups of the sample S1, S2, and S3 were compared to dexamethasone standard. To identify of TLC method, obtained Rf value of dexamethasone standard and the sample, visualizing a stain color purple-fluorescence on the UV 254 nm. The analysis of quantitative dexamethasone concentration using TLC-Densitometric showed the presence of dexamethasone in the sample for S1, S2 and S3. The concetration of dexamethasone obtained of sample S1, S2, S3 were 1014.64 µg/g ; 131.15 µg/g ; 135.54 µg/g respectively.

Rheumatic involvement and bone scan features in Schnitzler syndrome: initial and follow-up data from a single-center cohort of 25 patients

Objective To report on the characteristics and long-term course of rheumatic manifestations in Schnitzler syndrome (SchS). Methods A retrospective cohort study of patients with SchS followed between 2000 and 2020. Inclusion criteria included a diagnosis of SchS (Strasbourg criteria). All available bone scans were reviewed and scored according to the intensity and number of pathological sites. The scintigraphic score was compared with the clinical activity score, CRP level, and treatments. Results Twenty-five patients were included. Median age at diagnosis was 68 years. Eighty patients (72%) had SchS-related rheumatic pain. Most patients had a long-standing isolated rash before constitutional and/or rheumatic symptoms appeared. The monoclonal component level was usually very low (IgMκ in 22/25). Rheumatic pain predominated around the knees. Bone scans revealed abnormal tracer uptake in 15/18 (85%). The scintigraphic score correlated with clinical activity (r = 0.4, p < 0.02) and CRP level (r = 0.47, p < 0.01). The scintigraphic score was lower in patients receiving corticosteroids or IL1Ra (interleukin 1 receptor antagonist) than in untreated patients (median scores:2, 0, and 13, respectively; p < 0.05). Two patients developed Waldenström macroglobulinemia. Of the 22 surviving patients, median age at follow-up was 76 years. IL1Ra was used in 13 patients, with dramatic efficacy on both symptoms and bone scan features. Conclusions Rheumatic manifestations are very prevalent in SchS. However, bone pain can be misleading and contribute to misdiagnosis. Bone scan abnormalities are very prevalent and correlate with disease activity and treatments. IL1-Ra has a dramatic and durable efficacy but may not be required in every patient early on.

Rheumatic pain management: molecular aspects

Rheumatic diseases (RDs), including osteoarthritis and rheumatoid arthritis, are non-infectious slowly progressive incurable inflammatory diseases that lead to prolonged disability due to damage to the musculoskeletal system. Pain is a dominant symptom at any stage of these diseases, is directly related to joint functioning, and determines the quality of life in patients. Moreover, despite the significant successes of studying the role of inflammation and regulation of autoimmune processes, the pathogenetic mechanisms for the development and maintenance of pain in RDs are little investigated. The nociceptive mechanisms due to inflammation and/or joint structural impairment are involved in the development of rheumatic pain. In addition, the latter is also associated with impaired signaling in the nervous system and with psychological problems in patients.At the present stage, pain treatment includes non-pharmacological interventions, as well as the use of certain pharmacological agents, in particular opioids and narcotic drugs. However, despite significant successes in the design of drugs that relieve pain, at present, a significant proportion of patients with RDs still experience pain after therapy. When designing novel drugs for the treatment of pain, it is necessary to take into account the molecular mechanisms of its development in RDs. This review considers the features of the manifestations of pain, its molecular markers and mechanisms at different stages of the disease in patients with the two most common RDs, such as rheumatoid arthritis and osteoarthritis.

Pengaruh Pijat (Massage) terhadap Perubahan Intensitas Nyeri Rematik pada Lansia di Desa Kertapati Puskesmas Dusun Curup Bengkulu Utara

The purpose of this study was to determine the effect of massage on the intensity of rheumatic pain in the elderly in the village of Kertapati, Puskesmas, Dusun Curup, North Bengkulu. This research is a quantitative study using a quasi experimental research design with pre and post test design research designs. The sample in this study amounted to 10 people taken by purposive sampling technique. The analysis used is univariate analysis and bivariate analysis, the statistical test used is the t-dependent test. The results of the study, the average value of rheumatic pain before a massage intervention (massage) in the elderly in the village of Kertapati, Curup Hamlet North Bengkulu is 5.2 and after the intervention is 3.4. T-dependent test results found that there were significant differences in the value of pain before and after massage intervention (massage) with a value of 0,000. In conclusion, there is an effect of massage on the intensity of rheumatic pain in the elderly in the village of Kertapati, Puskesmas, Dusun Curup, North Bengkulu. It is expected to provide optimal nursing care, especially massage interventions to the elderly and can socialize massage skills to the elderly, so that they can independently massage when there is a pain attack.Keywords: Elderly, Rheumatic Pain, Massage

Perceived Influence of Weather Conditions on Rheumatic Pain in Romania

The main objective of this study was to analyze the perception of the influence of various weather conditions on patients with rheumatic pathology. A group of 394 patients, aged between 39 and 87 years and diagnosed with degenerative rheumatic diseases, were interviewed individually by using a questionnaire created specifically for this study. Further on, to assess the relationship between pain intensity and weather conditions, a frequency analysis based on Pearson’s correlation matrix was employed. The most important results are as follows: the great majority of the participants (more than 75%) believe that their rheumatic pain is definitely or to a great extent influenced by different weather conditions; most of the patients reported intensification of their pain with weather worsening, especially when cloudiness and humidity suddenly increase (83.8% and 82.0%, respectively), air temperature suddenly decreases (81.5%), and in fog or rain conditions (81.2%). In our research, alongside simple meteorological variables, we established that complex weather variables such as atmospheric fronts, in particular, the cold ones and winter anticyclonic conditions, greatly intensify the rheumatic pain, whereas summer anticyclonic conditions usually lead to a decrease in pain severity. In terms of relationships between pain intensity and weather conditions, we found the strongest correlations (ranging between 0.725 and 0.830) when temperature, relative humidity, and cloudiness are constantly high.