Abstract: There is a list of occupational diseases associated with risk factors including chemical ones at Russian Federation determined by Ministry of Health of Russian Federation Order №417н of 27.04.2012. In order to early diagnostics and to prevent morbidity increase of occupational diseases, associated with chemical factors it is required to perform preliminary and periodic medical examinations of employees whose work is associated with exposure to harmful and(or) hazardous risk factors, including chemical ones, determined by Ministry of Health of Russian Federation Order №29н of 28.01.2021. List of chemical factors given in the appendix of actual Order determined by cooperative Ministry of Labor and Social Protection and the Ministry of Health Order №998н/1420н of 31.12.2020. Due to comparison analysis of harmful and(or) hazardous risk chemical factors listed in Order №27н and Order №417н appendixes it was determined that there are a few factors approved as harmful and(or) hazardous chemical factors in Order №29н are not approved as ones in Order №417н, what means that diseases caused by these factors cannot be approved as occupational diseases. As a result of detected discrepancy it is proposed to supplement the list of occupational diseases associated with the impact of chemical factors.