Altered Dynamic Brain Connectivity in Individuals With Sickle Cell Disease and Chronic Pain Secondary to Hip Osteonecrosis

Individuals with sickle cell disease (SCD) exhibit changes in static brain connectivity in rest. However, little known as chronic pain associated with hip osteonecrosis affects dynamic brain connectivity during rest and the motor imagery task. The aim of this study was to investigate the characteristics of the dynamic functional brain connectivity of individuals with SCD and chronic pain secondary to hip osteonecrosis. This is a cross-sectional study comparing the dynamic brain connectivity of healthy individuals (n = 18) with the dynamic brain connectivity of individuals with SCD and chronic pain (n = 22). Individuals with SCD and chronic pain were stratified into high- or low-intensity pain groups based on pain intensity at the time of assessment. Dynamic brain connectivity was assessed through electroencephalography in 3 stages, resting state with eyes closed, and during hip (painful for the SCD individuals) and hand (control, nonpainful) motor imagery. Average weight of the edges and full synchronization time (FST)—time required for 95% of the possible edges to appear over time during a given task—were evaluated. Regarding the average weight of the edges, individuals with SCD and high-intensity pain presented higher edge weight during hip motor imagery. The average weight of the edges correlated positively with pain intensity and depression symptoms. Individuals with SCD and chronic pain complete the cerebral network at rest more quickly (lower FST). Individuals with SCD and chronic pain/hip osteonecrosis have impaired dynamic brain network with shorter FST in rest network and more pronounced diffuse connectivity in individuals with high-intensity pain. The dynamic brain network evaluated by time-varying graphs and motif synchronization was able to identify differences between groups.

Preparations with catastrophic side effects: A case of neck of femur fracture due to secondary osteoporosis with underlying hip osteonecrosis resulting from chronic jamu consumption

Jamu is commonly used to treat a variety of health conditions in South East Asia due to its efficacy, affordability and ease of access. Despite its effectiveness, little is known regarding its contents and adverse effects. Recent studies have found evidence of steroids within jamu preparations. Chronic jamu consumption may inadvertently manifest with adverse effects associated with long-term steroid intake. We describe a case of neck of femur fracture due to secondary osteoporosis with underlying hip osteonecrosis resulting from chronic jamu consumption hoping to increase awareness regarding the devastating effects of these preparations.