sf9 insect cells
Recently Published Documents


TOTAL DOCUMENTS

107
(FIVE YEARS 3)

H-INDEX

22
(FIVE YEARS 0)

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 891
Author(s):  
Braulio M. Fraga ◽  
Carmen E. Díaz ◽  
María Bailén ◽  
Azucena González-Coloma

Three new compounds, the sesquiterpenes absilactone and hansonlactone and the acetophenone derivative ajenjol, have been isolated from a cultivated variety of Artemisia absinthium. In addition, the major lactone isolated, 3α-hydroxypelenolide, was biotransformed by the fungus Mucor plumbeus affording the corresponding 1β, 10α-epoxide. A cadinane derivative was formed by an acid rearrangement produced in the culture medium, but not by the enzymatic system of the fungus. Furthermore, 3α-hydroxypelenolide showed strong antifeedant effects against Leptinotarsa decemlineata and cytotoxic activity to Sf9 insect cells, while the biotransformed compounds showed antifeedant postingestive effects against Spodoptera littoralis.


Author(s):  
Yixin Liu ◽  
Ana Pavić ◽  
Joshua T. Farley ◽  
Carine de Marcos Lousa ◽  
Adrian Goldman ◽  
...  

3 Biotech ◽  
2019 ◽  
Vol 9 (11) ◽  
Author(s):  
Alexandra Marisa Targovnik ◽  
Alejandro Ferrari ◽  
Gregorio Juan Mc Callum ◽  
Mariana Bernadett Arregui ◽  
Ignacio Smith ◽  
...  

Author(s):  
Thitaree Yooboon ◽  
Kazumu Kuramitsu ◽  
Vasakorn Bullangpoti ◽  
Yooichi Kainoh ◽  
Seiichi Furukawa

Vaccines ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 41 ◽  
Author(s):  
Lisa Nika ◽  
Sara Cuadrado-Castano ◽  
Guha Asthagiri Arunkumar ◽  
Clemens Grünwald-Gruber ◽  
Meagan McMahon ◽  
...  

Human epidermal growth factor receptor-2 (HER2) is upregulated in 20% to 30% of breast cancers and is a marker of a poor outcome. Due to the development of resistance to passive immunotherapy with Trastuzumab, active anti-HER2 vaccination strategies that could potentially trigger durable tumor-specific immune responses have become an attractive research area. Recently, we have shown that budded virus-like particles (VLPs) produced in Sf9 insect cells are an ideal platform for the expression of complex membrane proteins. To assess the efficacy of antigen-displaying VLPs as active cancer vaccines, BALB/c mice were immunized with insect cell glycosylated and mammalian-like glycosylated HER2-displaying VLPs in combination with two different adjuvants and were challenged with HER2-positive tumors. Higher HER2-specific antibody titers and effector functions were induced in mice vaccinated with insect cell glycosylated HER2 VLPs compared to mammalian-like glycosylated counterparts. Moreover, insect cell glycosylated HER2 VLPs elicited a protective effect in mice grafted with HER2-positive mammary carcinoma cells. Interestingly, no protection was observed in mice that were adjuvanted with Poly (I:C). Here, we show that antigen-displaying VLPs produced in Sf9 insect cells were able to induce robust and durable immune responses in vivo and have the potential to be utilized as active cancer vaccines.


2019 ◽  
Vol 21 ◽  
pp. e00295 ◽  
Author(s):  
Tang Li ◽  
Wenfa Zhang ◽  
Jianhua Hao ◽  
Mi Sun ◽  
Sheng-Xiang Lin

2018 ◽  
Vol 28 (10) ◽  
pp. 1683-1690
Author(s):  
Sung-Jin Yoon ◽  
Young-Jun Park ◽  
Hyun Ju Kim ◽  
Jinwoo Jang ◽  
Sang Jun Lee ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document