Comparative studies of the functioning of the respiratory system in children in conditions of health institutions

Summer health camp is a seasonal preventive institution for recreation, preservation and strengthening of the health of children and adolescents, which allows you to cover a large contingent of the child population with health-improving activities. The article presents the dynamics of the functional indicators of the respiratory system in children and adolescents who were in a summer health camp. On the basis of the children’s health camp «Young railroad worker» and the camp on the basis of a secondary educational school, research was carried out, in which children aged 7–10 years took part. Respiratory function was measured using a spirometer. The data obtained were analyzed using generally accepted methods of mathematical statistics. To identify the level of significance of differences, we used Student’s t-test.In children with round-the-clock stay in the camp, there is a statistically significant increase in Lung Capacity by 101.97 ml and a daytime stay — by 80.55 ml. At the end of the shift, summer health-improving recreation led to an increase in the indicators of the Respiratory Minute Volume (at the time of arrival, the Respiratory Minute Volume indicator in children 7–10 years old was 3,71 ± 1,03 l/min, and at the end 4,31 ± 1,88 l/min with round-the-clock stay; 3,65 ± 1,04 l/min and 4,1 ± 1,54 l/min with a daytime stay) due to an increase in Tidal Volume, which indicates a favorable respiratory response.The results of the functional study revealed an increase in the reserve capacity of the respiratory organs, which indicates the positive effect of the camp on the child’s body.The results obtained in the study of the functional state of respiration will make it possible to determine the directions and forms of organization of medical care in order to prevent deviations in the state of health. These results can serve as a basis for further in-depth research in summer camps of various types and the development of control measures and means of strengthening and maintaining the health of children. Thus, summer health camps are an effective measure of recreation and preservation, strengthening the health of the child population.

DYNAMICS OF INDEXES OF EXTERNAL BREATH AND BEHAVIOR ACTIVITIES OF WHITE RATS WHEN EXPOSED TO A SUBSTANCE OF THE CS TYPE

The indexes of external respiration of white rats exposed by inhalation to a substance of the CS type were estimated. Increase in the respiratory volume and respiratory minute volume as well as the absence of changes in respiratory rate when exposed to the formulation at the level of effective inhalation toxodosis has been found. It has been established that substance of the CS type causes a significant change in motor activity.

Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1

We studied respiratory functions in mutant mice deficient in endothelin-1 (ET-1) generated by gene targeting. In conscious adult mice heterozygous for ET-1 gene mutation (ET+/- heterozygous mice), arterial PO2 was significantly lower, PCO2 tended to be higher, and pH tended to be lower than in wild-type littermates. When these conscious mice breathed room air, respiratory minute volume and rate, determined by body plethysmography, were not significantly different between the two groups. However, when ET+/- heterozygous mice were subjected to systemic hypoxia (1:1 air-N2) or hypercapnia (5% CO2-95% O2), increases in respiratory minute volume were significantly attenuated. In conscious newborn ET-/- homozygous mice delivered by cesarean section and tracheotomized, ventilatory responses to systemic hypoxia and hypercapnia, regularly observed in newborn wild-type mice, were almost totally absent. In urethan-anesthetized adult ET+/- heterozygous mice, increases in phrenic nerve discharges in response to hypoxia and hypercapnia were significantly attenuated. Our results demonstrate that ventilatory responses to hypoxia and hypercapnia are impaired in ET-1-deficient mice and suggest that endogenous ET-1 participates in the physiological control of ventilation.