Anti-Cancer and Anti-Inflammatory Potential of the Green Synthesized Silver Nanoparticles of the Red Sea Sponge Phyllospongia lamellosa Supported by Metabolomics Analysis and Docking Study

Background: The Red Sea sponges have been endorsed as a plentiful source of bioactive compounds with promising anti-cancer and anti-inflammatory activities; therefore, exploring their potential as a source of anti-cancer metabolites has stimulated a growing research interest. Purpose: To investigate the anti-cancer and anti-inflammatory potential of the Red Sea sponges, in their bulk and silver nanostructure. Metabolomics analysis of the selected sponge followed by molecular docking studies, will be conducted to explore and predict the secondary metabolites that might provide its capability of inhibiting cancer. Materials and Methods: We prepared a chloroform extract (CE) and ethyl acetate extract (EE) of the Red Sea sponge Phyllospongia lamellosa synthesized silver nanoparticles. The prepared silver nanoparticles were characterized through UV–vis spectrophotometric, transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR) analyses. Testing for their anti-cancer activities was performed against MCF-7, MDB-231, and MCF-10A cells. Anti-inflammatory activity against COX-1 and 2 was assessed. Furthermore, liquid chromatography–mass spectrometry (LC–MS)-based metabolomics analysis and molecular docking were also applied.

Synthesis of silver nanostructure on gold nanoparticle using near field assisted second harmonic generation

By using gold (Au) nanoparticles (NPs) as an optical near-field source under far-field illumination in combination with a silver (Ag) ion solution containing a photoinitiator, we coated Ag on Au NPs using a near-field (NF)-assisted process. We evaluated the change in the size of the NPs using transmission electron microscopy. Evaluation of the synthesized Ag volume over illumination power confirmed the squared power dependence of the NP volume with illumination using 808 nm light, i.e., a wavelength longer than the absorption edge wavelength of the photoinitiator molecules. The rate of volume increase was much lower than the plasmonic field enhancement effect. Therefore, the squared power dependency of the volume increase using a wavelength longer than the absorption edge wavelength originated from NF-assisted second-harmonic generation and the resulting excitation.

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures

The significance of silver nanostructures has been growing considerably, thanks to their ubiquitous presence in numerous applications, including but not limited to renewable energy, electronics, biosensors, wastewater treatment, medicine, and clinical equipment. The properties of silver nanostructures, such as size, size distribution, and morphology, are strongly dependent on synthesis process conditions such as the process type, equipment type, reagent type, precursor concentration, temperature, process duration, and pH. Physical and chemical methods have been among the most common methods to synthesize silver nanostructures; however, they possess substantial disadvantages and short-comings, especially compared to green synthesis methods. On the contrary, the number of green synthesis techniques has been increasing during the last decade and they have emerged as alternative routes towards facile and effective synthesis of silver nanostructures with different morphologies. In this review, we have initially outlined the most common and popular chemical and physical methodologies and reviewed their advantages and disadvantages. Green synthesis methodologies are then discussed in detail and their advantages over chemical and physical methods have been noted. Recent studies are then reviewed in detail and the effects of essential reaction parameters, such as temperature, pH, precursor, and reagent concentration, on silver nanostructure size and morphology are discussed. Also, green synthesis techniques used for the synthesis of one-dimensional (1D) silver nanostructures have been reviewed, and the potential of alternative green reagents for their synthesis has been discussed. Furthermore, current challenges regarding the green synthesis of 1D silver nanostructures and future direction are outlined. To sum up, we aim to show the real potential of green nanotechnology towards the synthesis of silver nanostructures with various morphologies (especially 1D ones) and the possibility of altering current techniques towards more environmentally friendly, more energy-efficient, less hazardous, simpler, and cheaper procedures.

Silver nanoparticle-decorated titanium dioxide nanowire systems via bioinspired poly(L-DOPA) thin film as surface-enhanced Raman spectroscopy (SERS) platform, and photocatalyst

Silver nanostructure decorated-titanium dioxide (TiO2) nanocomposite systems with their unique characteristics provide extraordinary performances in various applications including surface-enhanced Raman spectroscopy (SERS), and photocatalysis. Despite the recent progress, novel, simple,...

Development of Nano-KIT for Synthesis of Silver and Gold Nanostructures with Emphasis on Biological Applications

Nano-KIT consist of few standard chemicals (solvents)/constitutes that can be added sequentially by given protocol. Spherical silver (30 nm) and gold (25–30 nm) nanostructure were synthesized instantly in (5–10 min). Surface plasmon resonance for silver 413 nm and gold 545 nm were confirmed synthesis. Synthesized silver has stability more than 36 months in cold condition. Dynamic Light Scattering (DLS), X-ray Diffraction (XRD) and High Resolution-Transmission Electron Microscopy (HR-TEM) revealed 30 nm (silver) and 25–30 nm (gold). Nano-KIT can be used for variety of application in Nano research areas like biomedical and industrial. Synthesized silver nanostructure were analysed with its molecular interaction between Bovine Serum Albumin (BSA). Biocompatibility assays with Red Blood Cells (RBC), number of binding sites, thermodynamic parameters i.e., free energy, enthalpy and entropy were studied.