Considerable electromotive forces are produced by the activity of excited muscles or nerves—up to three or four hundredths of a volt—and it was conceivable that an appreciable amount of energy might be involved in the currents set up in the tissue by them. This paper contains an examination of the question. In fig. 1 is shown a nerve fibre, on which rest electrodes (not shown) connected to an electrometer or galvanometer. Along the outside of the fibre is travelling, from right to left, a wave of negative potential, which velocity
a
cm. per second, having at any point distant
x
cm. along the nerve, and at time
t
seconds, a value
y
volts, as recorded on the electrometer, and shown (after the appropriate analysis) in the lower curve of the figure. We are not concerned here with the cause of this electromotive change, nor with what happens inside the fibre, but only with the physical results of it in an external circuit.