Time to scale up molecular surveillance for anti-malarial drug resistance in sub-saharan Africa

Artemisinin resistance has emerged and spread in the Greater Mekong Sub-region (GMS), followed by artemisinin-based combination therapy failure, due to both artemisinin and partner drug resistance. More worrying, artemisinin resistance has been recently reported and confirmed in Rwanda. Therefore, there is an urgent need to strengthen surveillance systems beyond the GMS to track the emergence or spread of artemisinin and partner drug resistance in other endemic settings. Currently, anti-malarial drug efficacy is monitored primarily through therapeutic efficacy studies (TES). Even though essential for anti-malarial drug policy change, these studies are difficult to conduct, expensive, and may not detect the early emergence of resistance. Additionally, results from TES may take years to be available to the stakeholders, jeopardizing their usefulness. Molecular markers are additional and useful tools to monitor anti-malarial drug resistance, as samples collected on dried blood spots are sufficient to monitor known and validated molecular markers of resistance, and could help detecting and monitoring the early emergence of resistance. However, molecular markers are not monitored systematically by national malaria control programmes, and are often assessed in research studies, but not in routine surveillance. The implementation of molecular markers as a routine tool for anti-malarial drug resistance surveillance could greatly improve surveillance of anti-malarial drug efficacy, making it possible to detect resistance before it translates to treatment failures. When possible, ex vivo assays should be included as their data could be useful complementary, especially when no molecular markers are validated.

The emergence of mind in Henry James’s notebook material

Inscribed in the field of cognitive narrative theory, this paper asks, and attempts to answer, a number of questions about the early emergence of mind in James’s notebook material for his short fiction. These questions essentially turn on the metarepresentational and aspectualizing potential of notebook entries in genetic relation to the finished tales, that is, on their capacity to present the projected storyworld, from its very conception, as a function of the subjectivity of one or several characters in the cognitive role of metarepresentational sources, or else as a dementalised lump of content to be aspectualised later in the process of execution. Analysis of the relevant notebook material yields a polarity between epistemic and contentual entries, and reveals a set of cognitive phenomena based on the alteration or continuity of the primitive balance of sources which allows one to conclude that James’s characteristic concern with the mental dynamics of his narratives, rather than being a compositional addition, was deeply embedded in his earliest fictional projects.

The Erotics of Urbanity

In the Conclusion, I draw on the analytical purchase of eroticism to provide a distinct vantage point onto the connections between urbanity, friendship, and spirituality. Adopting a different way of doing history in the field of early modern Persianate studies, I focus on a discrete moment in the story of Isfahan to think more broadly with historians of sexuality about the valences of erotic desires that bound together networks of friends living in previous centuries. Thinking sex with the early moderns compels me to see erasures that today silence passionate friendships and obscures the entangled history that love shared with eros and beauty. My history of Isfahan presents an early emergence of heteroerotic anxieties, provoked by the adab of urban love and Sufi homoerotic desire, that in the twentieth century were recuperated to make Iran modern.