free jejunal graft
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Author(s):  
Sune Brinck Erichsen ◽  
Josefine Slater ◽  
Birgitte Jul Kiil ◽  
Torben Ingemann Petersen ◽  
Niels Katballe ◽  
...  

Summary Background The role of surgery in treatment of locally advanced cervical esophageal cancer (CEC) remains debated. In the European and American treatment guidelines, definitive chemoradiotherapy (dCRT) is preferred over surgery, while in the Danish guidelines, the two treatment modalities are equally recommended. Surgical treatment of CEC is centralized at our center in Denmark. We present our outcomes following neoadjuvant chemoradiotherapy (nCRT) when possible and resection as first-line therapy for CEC and compare with recent published dCRT results. Method We retrospectively reviewed the medical charts of patients treated for cervical esophageal cancer at Aarhus University Hospital from 2001–2018 with nCRT when possible and pharyngolaryngectomy followed by reconstruction with a free jejunal graft. Results Forty consecutive patients were included. About, 45% received nCRT. The median survival was 21 months. The overall, disease-specific and disease-free 5-year survival was 43.6%, 53.2%, and 47.4%, respectively. The rate of microscopically radical resection was 85%. The recurrence rate was 47% and 81% of recurrences were locoregional. The in-hospital and 30-day mortality rate was 0%. Major complications occurred in 27.9%. Anastomotic leakage, graft failure, fistulas and strictures occurred in 10%, 7.5%, 30%, and 30%, respectively. Conclusion Our treatment offers equal oncological results compared to the best internationally published results for dCRT for CEC. Results vary considerably between dCRT studies. Morbidity appears more pronounced following surgery. Future studies are warranted to investigate the Danish national outcomes following dCRT as first-line treatment for curable locally advanced CEC.


2017 ◽  
Vol 41 (9) ◽  
pp. 2329-2336 ◽  
Author(s):  
Hiroshi Miyata ◽  
Keijiro Sugimura ◽  
Masaaki Motoori ◽  
Yoshiyuki Fujiwara ◽  
Takeshi Omori ◽  
...  

2016 ◽  
Vol 43 (6) ◽  
pp. 693-697 ◽  
Author(s):  
Takayuki Imai ◽  
Takahiro Goto ◽  
Ko Matsumoto ◽  
Koreyuki Kurosawa ◽  
Yukinori Asada ◽  
...  

2016 ◽  
Vol 4 (3) ◽  
pp. e632 ◽  
Author(s):  
Ayato Hayashi ◽  
Yuhei Natori ◽  
Masakazu Komoto ◽  
Takashi Matsumura ◽  
Masatoshi Horiguchi ◽  
...  

2015 ◽  
Vol 194 (2) ◽  
pp. 394-399 ◽  
Author(s):  
Kinji Kamiya ◽  
Naoki Unno ◽  
Shinichiro Miyazaki ◽  
Masaki Sano ◽  
Hirotoshi Kikuchi ◽  
...  

ORL ◽  
2015 ◽  
Vol 77 (5) ◽  
pp. 262-267 ◽  
Author(s):  
Song Ni ◽  
Yiming Zhu ◽  
Jian Wang ◽  
Dezhi Li ◽  
Bin Zhang ◽  
...  

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