collagen markers
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2019 ◽  
Vol 20 (1) ◽  
pp. 57-68 ◽  
Author(s):  
Anne Christine Bay-Jensen ◽  
Amalie Engstroem ◽  
Neha Sharma ◽  
Morten Asser Karsdal

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0203200 ◽  
Author(s):  
Nina Kimer ◽  
Natasja Stæhr Gudmann ◽  
Julie Steen Pedersen ◽  
Søren Møller ◽  
Mette Juul Nielsen ◽  
...  

2015 ◽  
Vol 35 (4) ◽  
pp. 1599-1608 ◽  
Author(s):  
Yanfei Wei ◽  
Minkui Huang ◽  
Xuemei Liu ◽  
Zhang Yuan ◽  
Yue Peng ◽  
...  

Background/Aims: Our previous studies have shown that plumbagin effectively inhibits hepatic stellate cell (HSC) proliferation. Thus, plumbagin-mediated anti-fibrotic effects in vivo merit further investigation. Methods: We used rat models to assess the potential benefits of plumbagin against CCl4-induced liver fibrosis. Results: The results showed that plumbagin lowered the serum concentrations of liver functional enzymes (ALT, AST, ALB, TBIL) in CCl4-fibrotic rats while reducing inflammatory cytokine levels (IL-6, TNF-a). As reflected in pathological examinations, rats that were administered plumbagin showed decreased collagen markers (HA, LN, PCIII and CIV) in liver tissues and improved hepatocellular impairments. In addition, plumbagin contributed to down-regulating NF-κB and TLR-4 mRNA in CCl4-lesioned livers. As revealed in the immunohistochemical assay, plumbagin-administered rats showed reduced levels of a-SMA and TNF-a immunoreactive cells in liver tissue. Conclusion: Collectively, these findings offer appealing evidence that plumbagin may serve as an anti-fibrotic medication through inactivating the NF-κB/TLR-4 pathway that is associated with inflammatory reactions, thereby mitigating liver fibrosis.


2012 ◽  
Vol 12 (1) ◽  
pp. 51-55 ◽  
Author(s):  
P. J. Lijnen ◽  
T. Maharani ◽  
N. Finahari ◽  
J. S. Prihadi

2012 ◽  
Vol 30 (9) ◽  
pp. 1405-1412 ◽  
Author(s):  
Sandra J. Shultz ◽  
Laurie Wideman ◽  
Melissa M. Montgomery ◽  
Kathleen N. Beasley ◽  
Bradley C. Nindl

2011 ◽  
Vol 4 (5) ◽  
pp. 561-568 ◽  
Author(s):  
Henry Krum ◽  
Maros Elsik ◽  
Hans G. Schneider ◽  
Agata Ptaszynska ◽  
Marion Black ◽  
...  

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 261
Author(s):  
Sandra J. Shultz ◽  
Laurie Wideman ◽  
Melissa M. Montgomery ◽  
Kathleen N. Beasley ◽  
Bradley C. Nindl

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