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Toxins ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 299
Author(s):  
Shaokang Wang ◽  
Da Pan ◽  
Ting Zhang ◽  
Ming Su ◽  
Guiju Sun ◽  
...  

Aflatoxin B1 (AFB1), which has potent toxicity and carcinogenicity, is a common contaminant of important agricultural commodities. This study aimed to investigate the frequency of corn flour intake and assess the exposure to AFB1 via direct detection of AFB1 in the diet and serum AFB1 exposure biomarker, so as to evaluate their associations with the risk of esophageal precancerous lesions (EPL). A case-control study based on three-day duplicate diet samples was performed in Huai’an District. One hundred EPL cases and 100 healthy controls were enrolled and required to be age- (±2 years) and gender-matched. The concentration of AFB1 in food samples and the level of serum AFB1-albumin (AFB1-Alb) adduct were quantitatively analyzed. Results showed that corn flour intake was positively associated with serum AFB1-Alb adduct level (p for trend = 0.003), dietary AFB1 exposure (p for trend < 0.001), and the risk of EPL (p for trend = 0.017). Increased serum AFB1-Alb adduct level was associated with an increased risk of EPL as well (p for trend < 0.001). In conclusion, corn flour may be an essential source of AFB1 in Huai’an District, whereas high exposure to AFB1 is likely to be an important risk factor contributing to the progression of EPL.


2018 ◽  
Vol 11 (3) ◽  
pp. 311-320 ◽  
Author(s):  
A. Kamala ◽  
C. Shirima ◽  
B. Jani ◽  
M. Bakari ◽  
H. Sillo ◽  
...  

In June 2016, an outbreak of an unknown disease was reported to affect clusters of families in two regions of the central part of Tanzania. A rapid epidemiological survey was conducted in the affected villages, with a detailed house-to-house survey in selected households. A total of 68 cases occurred between 14 May and 14 November 2016, of which 20 died, making a case fatality rate of 30%. Over 50% of the cases were below the age of 15 years. The cases presented with jaundice (n=60), abdominal pain (n=59), vomiting (n=56), diarrhoea (n=34) and ascites (n=32). The responsible food item appeared to be home grown maize. The rate ratio indicated that the occurrence of illnesses was associated with ingestion of food contaminated with high levels of aflatoxins (contamination range: 10-51,100 μg/kg and 2.4-285 μg/kg for case and control households, respectively). Serum aflatoxin biomarker indicated that cases were more likely to have higher than 1000 pg/mg aflatoxin-albumin adduct level in their sera compared to controls (Odds Ratio = 13.5; 95% confidence intervals = 1.5-165.3; range of aflatoxin-albumin adduct level = 36- 32,800 pg/mg for cases and 10-4020 pg/mg for controls). Beside aflatoxins, maize samples were also contaminated with high levels of fumonisins (range of contamination; 945-12,630 μg/kg) with 8 of 10 samples analysed from case households co-contaminated with both toxins at levels above the maximum limit of 5 or 10 μg/kg set for AFB1or total aflatoxins and 2,000 μg/kg for fumonisins. Clinical presentation and high levels of aflatoxin in food samples coupled with high levels of serum aflatoxin-albumin adducts among the cases support the causal role of aflatoxins.


2013 ◽  
Vol 58 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Chun-Yi Chuang ◽  
Jai-Nien Tung ◽  
Mao-Chang Su ◽  
Buor-Chang Wu ◽  
Chun-Han Hsin ◽  
...  

Biomarkers ◽  
2010 ◽  
Vol 15 (7) ◽  
pp. 575-582 ◽  
Author(s):  
Alberto Izzotti ◽  
Alessandra Pulliero ◽  
Riccardo Puntoni ◽  
Marco Peluso ◽  
Rosangela Filiberti ◽  
...  

2005 ◽  
Vol 50 (3) ◽  
pp. 525-532 ◽  
Author(s):  
Peng Tao ◽  
Liu Zhi-Ming ◽  
Liu Tang-Wei ◽  
Li Le-Qun ◽  
Peng Min-Hao ◽  
...  

2003 ◽  
Vol 37 (9) ◽  
pp. 947-956 ◽  
Author(s):  
Ulla Vogel ◽  
Bahram Danesvar ◽  
Lotte Risom ◽  
Allan Weimann ◽  
Henrik Enghusen Poulsen ◽  
...  

2000 ◽  
Vol 36 (11) ◽  
pp. 1381-1388 ◽  
Author(s):  
Y.-W Cheng ◽  
C.-Y Chen ◽  
P Lin ◽  
C.-P Chen ◽  
K.H Huang ◽  
...  

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