Integration of ERT, IP and SP Methods in Hard Rock Engineering

Investigation of a hard rock site for the development of engineered structures mainly depends on the delineation of weathered and unweathered rock, and the fractures/faults. Traditionally, borehole tests are used in such investigations. However, such approaches are expensive and time-consuming, require more equipment, cannot be conducted in steep topographic areas, and provide low coverage of the area with point measurements only. Conversely, geophysical methods are non-invasive, economical, and provide large coverage of an area through both vertical and lateral imaging of the subsurface. The geophysical method, electrical resistivity tomography (ERT), can reduce a significant number of expensive drilling tests in geotechnical investigations. However, a geophysical method alone may provide ambiguity in the interpretation of the subsurface, such as electrical resistivity cannot differentiate between water and clay content. Such uncertainty can be improved by the integration of ERT with induced polarization (IP). Similarly, self-potential (SP) can be integrated with other geophysical methods to delineate the groundwater flow. In this contribution, we integrated three geophysical methods (ERT, IP and SP) to delineate the weathered and unweathered rock including the weathered/unweathered transition zone, to detect the fractures/faults, and to map the groundwater flow. Based on ERT, IP and SP results, we develop a geophysical conceptual site model which can be used by site engineers to interpret/implement the findings for build-out. Our approach fills the gaps between the well data and geological model and suggests the most suitable places for the development of engineered structures in the hard rock terrains.

Engineered hyporheic zones: design and applications in stream health restoration- a review

Anthropogenic deterioration of streams and rivers have affected their surface-subsurface linkages. This has led to the degradation of hyporheic zones, a sensitive interface between stream channel and its surrounding sediments, responsible for transforming pollutants, natural solutes and supporting benthic communities. Several authors have reported the influence of stream restoration measures on hyporheic exchanges and have called for the inclusion of hyporheic zone restorations in stream management. Engineered Hyporheic Zones (EHZ) is the creation of artificial transition area due to induced hyporheic flows, brought about by some feature modifications done to the stream channel or its subsurface. These feature modifications and its implications have been investigated through lab experiments, outdoor flumes, modelling and field studies for several years. This paper attempts to summarize the endeavours made in the study of EHZ and its applications in water quality improvement and habitat restoration. A comprehensive review of upto date literature with specific focus on the influence of engineered structures on hyporheic exchanges is presented, followed by the comparison of preferences opted for different studies and their limitations. The paper ends with suggestive future scope in EHZ studies and its potential as a low cost alternative treatment technology for river restoration.

Ensuring radiation safety during temporary storage of solidified radioactive waste in light hangar-type facilities

Expensive permanent storage facilities with massive engineered structures are used traditionally to ensure safe temporary storage of solidified radioactive waste at the NPP sites. Such approach is dictated by the need to comply with the regulatory requirements for limiting the gamma background in the area adjacent to the storage facility. The costs involved in temporary storage of solidified RW can be optimized by using light hangar-type storage facilities. At the same time, the safety of storage, including radiation protection of the personnel, the public and the environment, is undoubtedly ensured through the use of special organizational and engineering solutions. The Novovoronezh NPP, a branch of JSC Concern Rosenergoatom, operates successfully light hangar-type facilities for temporary storage of solidified RW classified as medium-level waste in accordance with OSPORB-99/2009. In the process of operation, a methodology and a method for conditioning and temporary storage of solidified RW were developed to ensure the RW removal for final disposal with no extra process operations and unreasonable costs. A methodology has been developed to assess the radiation situation around storage facilities during temporary storage of RW, as well as a software package for predicting the radiation situation when deciding on the arrangement of the storage facility’s peripheral rows.

GENERATIONS OF WARFARE AND THE FUTURE OF THE HYBRID WARS

The article is about the generations of war and expounds on Hybrid wars. Its connection to the model of generational divisions is detailed. Today, as well, with the Cold War is over, the hyperactivity of the US in the military-political arena has brought forth a similar storm. The American war machine is in a victory march. At the same time a variety of ideas and theories of war are brought forth and being discussed. There are differing views on how generations of war should be classified. In my opinion, the main spheres of human development, such as that of commerce, economics, politics, science, education and culture, are the main determining factors. Taking into consideration the various factors, wars have been divided into the following six generations. Fifth generation warfare's necessity became apparent during fourth generation wars. The main elements in question were automated control systems and precision-guided armament. Along with new political, economic and social developments, these ensured new victories. Again, in this generation, armies chose to avoid operations that required large scale mobilization, and instead tried promptly sending small groups into battle, avoiding large-scale preparatio. The issues in the fields of war, as well as the issue of waves of communication, reached their peak. This generation, once and for all, confirmed the importance of force accumulation on any platform, anywhere in the world. Fifth generation wars brought armies to a point where they retired from classical combined arms warfare; Electro-Fire Battle is more commonly applied. Trenches and engineered structures are nearly extinct. This was yet another example of believing in the superiority of quality over quantity. The effects of information became a decisive factor. These were the wars of the digital media industry.

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies. Mutated Fc regions and monoclonal antibodies that target FcRn are currently in clinical development and hold promise for reducing the levels of circulating IgG. Additionally, engineered structures containing multimeric Fc regions allow the dual targeting of FcRn and FcγRs; however, their tolerance needs to first be validated in phase I clinical studies. Here, for the first time, we have developed a modified monomeric recombinant Fc optimized for binding to all FcRns and FcγRs without the drawback of possible tolerance associated with FcγR cross-linking. A rational approach using Fc engineering allowed the selection of LFBD192, an Fc with a combination of six mutations that exhibits improved binding to human FcRn and FcγR as well as mouse FcRn and FcγRIV. The potency of LFBD192 was compared with that of intravenous immunoglobulin (IVIg), an FcRn blocker (Fc-MST-HN), and a trimeric Fc that blocks FcRn and/or immune complex-mediated cell activation through FcγR without triggering an immune reaction in several in vitro tests and validated in three mouse models of autoimmune disease.