Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application

ELIMED has been developed and installed at ELI beamlines as a part of the ELIMAIA beamline to transport, monitor, and use laser-driven ion beams suitable for multidisciplinary applications, including biomedical ones. This paper aims to investigate the feasibility to perform radiobiological experiments using laser-accelerated proton beams with intermediate energies (up to 30 MeV). To reach this goal, we simulate a proton source based on experimental data like the ones expected to be available in the first phase of ELIMED commissioning by using the G4-ELIMED application (an application based on the Geant4 toolkit that simulates the full ELIMED beamline). This allows the study of transmission efficiency and the final characteristics of the proton beam at the sample irradiation point. The Energy Selector System is used as an active energy modulator to obtain the desired beam features in a relatively short irradiation time (around 6 min). Furthermore, we demonstrate the capability of the beamline to filter out other ion contaminants, typically co-accelerated in a laser-plasma environment. These results can be considered as a detailed feasibility study for the use of ELIMED for various user applications such as radiobiological experiments with ultrahigh dose rate proton beams.

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.

Enhancement of the Mechanical Properties of Polyimide Film by Microwave Irradiation

Polyimide films have conventionally been prepared by thermal imidization of poly(amic acid)s (PAAs). Here we report that the improvement of tensile strength while increasing (or maintaining) film flexibility of polyimide films was accomplished by simple microwave (MW) irradiation of the PAAs. This improvement in mechanical properties can be attributed to the increase in molecular weight of the polyimides by MW irradiation. Our results show that the mechanical properties of polyimide films can be improved by MW irradiation, which is a green approach that requires relatively low MW power, very short irradiation time, and no incorporation of any additional inorganic substance.

Greywater treatment by constructed wetlands in combination with TiO2-based photocatalytic oxidation for suburban and rural areas without sewer system

In this study greywater treatment through constructed wetlands and subsequently through TiO2-based photocatalytic oxidation was investigated. Through constructed wetlands treatment the organic substances have been reduced greatly. For further removal of organic substances and pathogens, a TiO2-based photocatalytic oxidation process was used subsequently. The results showed that the treated greywater through constructed wetlands and subsequent through TiO2-based photocatalytic oxidation with short irradiation time (3 hours irradiation time) met the requirements of European bathing water quality easily. Therefore, the greywater treated with the processes combination can directly be reused for non-potable purposes. Moreover, since residual organic substances through TiO2-based photocatalytic oxidation with long irradiation time can be eliminated almost totally, it is also possible that treated greywater is used for groundwater recharge as a drinking water resource.