isthmic nucleus
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2011 ◽  
Vol 31 (16) ◽  
pp. 6088-6097 ◽  
Author(s):  
A. Asadollahi ◽  
S. P. Mysore ◽  
E. I. Knudsen

1999 ◽  
Vol 48 (3) ◽  
pp. 343-350 ◽  
Author(s):  
Edit Pollák ◽  
Gyula Lázár ◽  
Róbert Gábriel ◽  
Shou-Rong Wang

1994 ◽  
Vol 346 (2) ◽  
pp. 306-320 ◽  
Author(s):  
Pál Tóth ◽  
Gyula Lázár ◽  
Shu-Rong Wang ◽  
Tong-Bin Li ◽  
Jia Xu ◽  
...  

1988 ◽  
Vol 177 (4) ◽  
pp. 325-330 ◽  
Author(s):  
Roger McCart ◽  
Charles Straznicky

Development ◽  
1987 ◽  
Vol 101 (4) ◽  
pp. 869-876
Author(s):  
C. Straznicky ◽  
R. McCart

The isthmic nucleus (IN) is a visual relay centre of the frog brain. It receives afferent projection from the optic tectum of the same side and projects bilaterally to both tecta. In young postmetamorphic Xenopus frogs, the survival of neurones in the IN on both sides was studied following the complete removal of the right tectum. In 6- to 8-week-old frogs, the right tectum was surgically removed and the operated animals allowed to survive for 1 to 13 weeks after operation. In selected animals, 3 days before the intended sacrifice, the postoptic commissure was transected and the cut isthmotectal fibres filled with horseradish peroxidase (HRP). In serial paraffin sections of the midbrain, the numbers of surviving and dying (pyknotic) neurones in the left and right IN were counted. The soma size of viable isthmic neurones and the volume of both IN were measured. Pyknotic neurones were seen between 1 and 6 weeks after operation in both the left and right IN, although the rate of cell loss was much greater in the latter. Virtually all the neurones of the right IN degenerated by 6 weeks after tectal ablation. In contrast, approximately 60% of neurones of the left IN survived. HRP histochemistry showed labelled isthmic neurones both in the left and right IN up to 3 weeks after operation. Thereafter, HRP-labelled neurones appeared only in the left IN. These observations indicate that the removal of the natural target of isthmic neurones brings about severe neurone death.(ABSTRACT TRUNCATED AT 250 WORDS)


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