Relationship Between F2 Slope and Intelligibility in Parkinson's Disease: Lexical Effects and Listening Environment

Purpose There is a complex relationship between speech production and intelligibility of speech. The current study sought to evaluate the interaction of the factors of lexical characteristics, listening environment, and the 2nd formant transition (F2 slope) on intelligibility of speakers with Parkinson's disease (PD). Method Twelve speakers with PD and 12 healthy controls read sentences that included words with the diphthongs /aɪ/, /ɔɪ/, and /aʊ/. The F2 slope of the diphthong transition was measured and averaged across the 3 diphthongs for each speaker. Young adult listeners transcribed the sentences to assess intelligibility of words with high and low word frequency and high and low neighborhood density in quiet and noisy listening conditions. The average F2 slope and intelligibility scores were entered into regression models to examine their relationship. Results F2 slope was positively related to intelligibility in speakers with PD in both listening conditions with a stronger relationship in noise than in quiet. There was no significant relationship between F2 slope and intelligibility of healthy speakers. In the quiet condition, F2 slope was only correlated with intelligibility in less-frequent words produced by the PD group. In the noise condition, F2 slope was related to intelligibility in high- and low-frequency words and high-density words in PD. Conclusions The relationship between F2 slope and intelligibility in PD was affected by lexical factors and listening conditions. F2 slope was more strongly related to intelligibility in noise than in quiet for speakers with PD. This relationship was absent in highly frequent words presented in quiet and those with fewer lexical neighbors.

An Electrophysiological Study of the Effects of Orthographic Neighborhood Size on Printed Word Perception

In two experiments participants read words and pseudo-words that belonged to either large or small lexical neighborhoods while event-related brain potentials (ERPs) were recorded from their scalps. In Experiment 1, participants made speeded lexical decisions to all items, while in Experiment 2 they engaged in a go/no-go semantic categorization task in which the critical items did not require an overt behavioral response. In both experiments, words and pseudo-words produced a consistent pattern of ERP effects: items with many lexical neighbors (large neighborhoods) generated larger N400s than similar items with relatively fewer lexical neighbors (small neighborhoods). Reaction time (RT, Experiment 1), on the other hand, showed a different pattern consistent with previous behavioral studies. While words tended to produce a facilitation in RT for larger neighborhoods, pseudowords produced an inhibition effect. The findings are discussed in terms of recent theories of word recognition and the functional significance of the N400.