Foetal hydrops: new challenges

Background Foetal Hydrops (FH) is an abnormal accumulation of fluid inside two or more serous cavities and may be linked with polyhydramnios and/or placental oedema. It has been correlated with several causes such foetal anaemia, chromosomal anomalies, congenital abnormalities, infections, twin-to-twin transfusion syndrome and maternal causes such as diabetes. Regardless the advances in diagnosis and therapy, the overall perinatal mortality rate remains high. Thereby, the main goal is to evaluate the autopsy findings including between 2010 and 2019. Methods 105 cases including perinatal and new-born autopsies with different gestation stages were studied, in order to understand the macroscopic and microscopic events that can elucidate FH. Results Macroscopically, a large number of foetuses demonstrated oedema effusions and intrauterine growth restriction. Regarding placenta, the most common macroscopic finding is oedema, such as described in the literature. Nodules and hemorrhagic areas are the new findings observed. Oedema remains the most relevant microscopic finding, whereas unspecified villi alterations and trophoblast pseudoinclusions were the new findings. Conclusions The results allowed the identification of new characteristics that can contribute to the knowledge of this foetal condition that remains a challenge. Future studies need to focus on identifying strategies for diagnosis and treatment is critical for foetal hydrops.

COMPARATIVE STUDY FOR USING OF SUB MUCOSA OF SMALL INTESTINE IN HEALING OF CLEAN AND INFECTED AVULSION WOUNDS

This study was done on 29 mature rabbits to observe the effect of sub mucosa of small intestine of sheep inthe healing of avulsion wound in rabbits, animals divided to three equal groups:First group: The avulsion wound in the thigh region was left without treatment, just covering with bandage andconsidered as a control group.Second group: Treatment of clean avulsion wound in the thigh region was done by covering it with sub mucosaof small intestine which previously prepared.Third group: Treatment of infected avulsion wound in the thigh region was done by covering it with sub mucosaof small intestine which previously prepared.The results of this study show that the sub mucosas of small intestine have the ability to enhance healing of thewound with little formation of scar tissue.The macroscopic finding show the faster in approximation of wound edges in groups two and three in the secondweek and with little formation of granulation and the wound site be similar to normal skin in the third week ascompared with control group in which the healing occur by formation of scar tissue observed in the third weekand continue to the forth week, while The histopathological finding show faster in organization of granulationtissue in the second week in groups two and three and the tissue appeared similar to normal skin in the third week,while in control group show increase in formation of granulation tissue which continue until the third week

Colonic Involvement in a Patient with Chronic Lymphocytic Leukaemia

Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon. If a CLL patient has any symptoms suggesting a possible GI manifestation of the haematologic disease or anaemia not explained by bone marrow infiltration or hemolysis, the diagnostic evaluation should include endoscopies with adequate biopsies.

Bovine demodicosis: a case report

Tissues samples collected at necropsy from a 9 year-old Holstein cow were fixed in buffered 10% formalin for histological examination. Macroscopic finding did not reveal typical nodular cutaneous lesions. Vulvar microscopic sections of cutaneous tegument showed mites (Demodex bovis), alone and grouped in hair follicles and sebaceous glands.

Feline infectious peritonitis (FIP) in our section material

Feline infectious peritonitis (FIP) has been diagnozed in our section material in 23 cats, 19 Persian and 4 domestic, of both sexes, aged between 5 months and 8 years. The majority of the infected population were animals under 20 months of age. The macroscopic finding in most cats was of granulomatous character, and large quantities of goldenyellow gelatinous exudate were observed in the stomach cavity of 7 animals, corresponding to the exudative form of FIP. Granulomas were in most cases located in the abdomen wall, liver, spleen, omentum and serous membrane of intestines, and the histological structure was characterized by fibrinoid-necrotic centers with numerous lymphocytes, monocytes, angioblasts and fibroblasts. Immunohistochemically, feline corona virus (FCV) antigens were exprimed in the cytoplasm of macrophages, more rarely in plasma cells in granulomas, and sometimes in necrotized areas.