Evaluation of fireground exposures using urinary PAH metabolites

Background Firefighters have increased cancer incidence and mortality rates compared to the general population, and are exposed to multiple products of combustion including known and suspected carcinogens. Objective The study objective was to quantify fire response exposures by role and self-reported exposure risks. Methods Urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons (PAH-OHs) were measured at baseline and 2–4 h after structural fires and post-fire surveys were collected. Results Baseline urine samples were collected from 242 firefighters. Of these, 141 responded to at least one of 15 structural fires and provided a post-fire urine. Compared with baseline measurements, the mean fold change of post-fire urinary PAH-OHs increased similarly across roles, including captains (2.05 (95% CI 1.59–2.65)), engineers (2.10 (95% CI 1.47–3.05)), firefighters (2.83 (95% CI 2.14–3.71)), and paramedics (1.84 (95% CI 1.33–2.60)). Interior responses, smoke odor on skin, and lack of recent laundering or changing of hoods were significantly associated with increased post-fire urinary PAH-OHs. Significance Ambient smoke from the fire represents an exposure hazard for all individuals on the fireground; engineers and paramedics in particular may not be aware of the extent of their exposure. Post-fire surveys identified specific risks associated with increased exposure.

Burn Prevention in the Elderly: Identifying Age and Gender Differences in Consumer Products Associated With Burn Injuries

Elderly suffer worse outcomes from burns; thus, it is important to identify the causes of burns in the elderly to develop burn prevention campaigns. We performed a 10-year review of burns that were registered in the NEISS database. We included patients at least 65 years old and analyzed the top five products that caused burn injury. In adults 65 to 74 years old, hot water was the most common cause of burns. Women suffered more burns by candles and cookware. Heaters/heating systems and gasoline were among the top five causes of burns in only men. For the age group 75 to 84 years old, the most common burn was from hot water in women and gasoline in men. For women, the top five included candles, nightwear, and cookware. Only men suffered gasoline burns. The majority of daywear, home/room fire, and ranges/ovens caused burns occurred in men. The majority of burns from hot water, ranges/ovens, electric heating pads, and bathtubs/showers occurred in women. For men, burns from gasoline, structural fires, and heaters are more prevalent. This data can be used to develop age- and gender-specific prevention campaigns to reduce the risk of burn injury.

Objective Measurement of Carcinogens Among Dominican Republic Firefighters Using Silicone-Based Wristbands

PURPOSE Firefighters around the world are exposed to physical hazards and toxic chemical agents during fire incident response. Occupational epidemiologic studies of the firefighter workforce have documented an excess cancer risk for brain, digestive, genitourinary, and lymphohematopoietic organs compared with the general population. Despite the elevated cancer risk, little is known about what specific types of carcinogenic chemicals first responders encounter during a typical work shift, particularly in low-resources settings, like the Dominican Republic. This pilot study characterizes objective measurements of carcinogenic exposure using passive sampling silicone-based wristbands among Dominican firefighters. METHODS Firefighters from a metropolitan fire service in the Dominican Republic were asked to wear a silicone-based wristband during one typical 24-hour shift. A pre- and postshift survey was administered to the firefighter to assess their self-reported sociodemographic, employment, and work shift characteristics. Wristbands were collected after their 24-hour shift and processed for the type and quantity of polycyclic aromatic hydrocarbons (PAHs), a family of known carcinogenic compounds, to which firefighters were exposed. RESULTS Among 15 firefighters who wore a wristband during their 24-hour shift, 73.3% responded to a fire with an average of 3.7 calls during the shift. Fire incident responses included structural fires (54.5%), outside and other fires (36.4%), and vehicle fires (9.1%). Total PAH exposure was significantly higher among Dominican firefighters who responded to a fire compared with firefighters with no fire during their shift (261 parts per billion [ppb] v 117 ppb, respectively; P = .003). Among the 19 PAHs quantified, low-molecular-weight phenanthrene was present in the highest concentration (32 ppb) among firefighters not responding to fires. CONCLUSION Passive objective sampling of PAHs using silicone-based wristbands among Dominican firefighters showed direct exposure to carcinogenic compounds during a typical 24-hour firefighter shift. Firefighters not attending a fire had lower levels of PAHs, suggesting carcinogenic contaminants are present at the fire station.

Tracking Precarious Aerial Swaggers using IoT-Enabled Drone

Emergency response teams are accused with ensuring citizen safety from life-threatening events such as structural fires, gas leakages, vehicle accidents, and precarious material spills. While overseeing such occasions is dangerous, the release of precarious materials, such as toxic chemicals, into the atmosphere is particularly challenging. Upon landing in a scene, response teams must quickly identify the precarious substance and the contaminated area to limit exposure to nearby population centres. For airborne toxins, this appraisal is confounded by natural conditions, for example, alters in wind speed and course that can cause unstable, elevated swaggers to move powerfully. Without a way to dynamically monitor and assess atmospheric conditions during these events, response teams must conservatively predict the extent of the contaminated area, then orchestrate evacuations, and reroute traffic to ensure the safety of nearby populations. In this paper, we propose outfitting drone with Internet of Things (IoT) sensor platforms to enable dynamic tracking of precarious aerial swaggers. Augmenting drone with sensors enables emergency response teams to maintain safe distances during precarious identification, minimizing first response team exposure. Additionally, we integrate sensor-based particulate detection with autonomous drone flight control providing the capability to dynamically identify and track the boundaries of aerial swaggers in real time. This empowers specialists on call for outwardly recognize swagger development and better foresee and disconnect the effect zone. We describe the composition of our prototype IoT-enhanced drone system and describe our initial evaluations.

Repair of Fire-Damaged Reinforced Concrete Members with Axial Load: A Review

It is common knowledge that structural fires have led to a great loss of buildings and damage to property in the past two decades. Therefore, there is a growing need to provide approaches for post-fire repair of structural members to enhance their structural safety. This paper presents a state-of-the-art review on the repair of fire-damaged reinforced concrete (RC) members with axial load. The investigations into the effects of loading method, physical dimension and bonding behavior on the residual strength of members are presented. In the meantime, the available experimental investigations on the performance of fire-damaged RC members with axial load repaired with concrete jacketing, steel jacketing and fiber-reinforced polymer (FRP) jacketing are summarized. Moreover, models for predicting the residual strength of fire- damaged columns are reviewed.

Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury

Smoke inhalation associated with structural fires, wildfires, or explosions leads to lung injury, for which innovative and clinically relevant animal models are needed to develop effective therapeutics. We have previously reported that damage-associated molecular patterns (DAMPs) and anti-inflammatory cytokines correlate with infectious complications in patients diagnosed with inhalational injury. In this study, we describe a novel and translational murine model of acute inhalational injury characterized by an accumulation of protein and neutrophils in the bronchoalveolar space, as well as histological evidence of tissue damage. Mice were anesthetized, and a cannula was placed in the trachea and exposed to smoldering plywood smoke three times for 2-min intervals in a smoke chamber. Here we demonstrate that this model recapitulates clinically relevant phenotypes, including early release of double-stranded DNA (dsDNA), IL-10, monocyte chemoattractant protein (MCP)-1, and CXCL1 along with neutrophilia early after injury, accompanied by subsequent susceptibility to opportunistic infection with Pseudomonas aeruginosa. Further investigation of the model, and in turn a reanalysis of patient samples, revealed a late release of the DAMP hyaluronic acid (HA) from the lung. Using nitric oxide synthase-deficient mice, we found that Nos2 was required for increases in IL-10, MCP-1, and HA following injury but not release of dsDNA, CXCL1 expression, early neutrophilia, or susceptibility to opportunistic infection. Depletion of CXCL1 attenuated early neutrophil recruitment, leading to decreased histopathology scores and improved bacterial clearance in this model of smoke inhalation. Together, these data highlight the potential therapeutic benefit of attenuating neutrophil recruitment in the first 24 h after injury in patients.

MITIGATION SCENARIOS FOR RESIDENTIAL FIRES IN DENSELY POPULATED URBAN SETTLEMENTS IN SUKAHAJI VILLAGE, BANDUNG CITY

Residential fires are a form of disaster that often occurs in urban areas especially in densely populated settlements. This study looks at possible mitigation scenarios for this kind of disaster. A case study was conducted in Babakan Ciparay Sub-District in Bandung City, among the densely populated settlements, and was focused especially on Sukahaji Village, a sub-unit of Babakan Ciparay, which is the most densely populated village in Bandung City with up to 234.14 people/ha. There have been six structural fires recorded from 2007 until 2010 occurring in Sukahaji. This study applied stratified random sampling as the preferred sampling technique and data collection method from a total population of 3,227 buildings. The data was then examined using risk analysis. The results have led to two intervention measures suggested as mitigation scenarios for residential fires that can be applied within the Sukahaji Village. The study concludes that mitigation measures through strengthening community capacity can be the principal option in reducing risk to fires in densely populated urban settlements.