Perawatan Paliatif terhadap Kualitas Hidup Pasien Kanker Payudara

This study aims to identify the effect of palliative care on breast cancer patients' quality of life. The method used in this study is a literature review. The results showed that palliative care affected breast cancer patients. In conclusion, comprehensive palliative care from various aspects of the patient's life plays a significant role in achieving the maximum quality of life in breast cancer patients and preparing for a dignified death. Keywords: Breast Cancer, Quality of Life, Palliative Care

Aproximación completa del genoma del cáncer de mama basal

Aproximación completa del genoma del cáncer de mama basal Whole genome approach to basal like breast cancer Mev Dominguez, Yannick Bidet Y, Maud Privat, Nancy Uhrhammer, Anne Cayre1, Ines Raoelfils, Frederick Penault-Llorca, Yves Jean Bignon Laboratoire Diagnostic Génétique et Moléculaire, Centre Jean Perrin, Clermont-Ferrand, France. Clermont Université, EA4233, Clermont-Ferrand, France. DOI: https://doi.org/10.33017/RevECIPeru2011.0007/ RESUMEN El cáncer de mama basal (BLBC) comprende hasta el 15% de los cánceres de mama. El BLBC es caracterizado por la baja o ausencia de la expresión del receptor de estrógreno (ER), receptor de progesterona (PR), ausencia de amplificación del gen HER2 y por la expresión de las citoqueratinas basales (Cks): Cks 5, 6, 14 y/o 17, receptor del factor de crecimiento epidermal (EGFR) y/o C-Kit. BLBC constituye una entidad clínica distinta y presenta un pobre prognóstico clínico (Sørlie et al. 2001). El principal objetivo de este proyecto es el mapeamiento completo y comparativo de las alteraciones genómicas en BLBC asociado o no con mutaciones en el gen BRCA1. Asi también, explorar el rol de la via de señalización de BRCA1 en BLBC. Por esta razón, utilizamos un arreglo de captura del exoma completo de 2.1M en 9 muestras congeladas de mama obtenidas del Departamento de Patología del Centre Jean Perrin-Clermont Ferrand. Actualmente, hemos identificado en un individuo (MCD-4) 11, 109 variantes, de las cuales 7,113 (64%) han sido descritas como polimorfismos (SNP) de acuerdo al algortimo conservativo HCDiff. Con relación a la distribución de estas variantes, los cromosomas 10 y 2 fueron los más afectados. Las nuevas variantes somáticas encontradas serán confirmadas por secuenciación convencional. El análisis de los pacientes remanentes está en avance. Mediante el empleo de esta medotología de nueva generación, nosotros contribuiremos en identificar nuevos marcadores o alvos terapéuticos así como ayudar a completar el catálogo de las variantes somáticas recurrentes y hereditarias asociadas con el desarrollo de BLBC. Keywords: Breast cancer, Basal like, BRCA1, genomic, mutation, next generation sequencing. ABSTRACT Basal like breast cancer (BLBC) composes up to 15% of breast cancer (BC) and is characterized by low or absent expression of estrogen receptor (ER), progesterone receptor (PR), lack of HER2 gene amplification and expression of basal cytokeratins (Cks) 5, 6, 14 and/or 17, epidermal growth factor receptor (EGFR) and/or C-Kit. BLBC constitutes a distinct clinical entity and is associated with poorer clinical outcome (Sørlie et al. 2001). The principal objective of this project is the complete and comparative mapping of genomic abnormalities in a series of BLBC associated or not to BRCA1 mutations and explores the role of the BRCA1 pathway in BLBC. For this reason, we are evaluating a 2.1 M feature human exome capture array on 9 frozen samples obtained from the Pathology Department of Centre Jean Perrin. By the time, we identified on one individual (MCD-4) 11,109 variants, of which 7,113 (64%) were described as known single nucleotide polymorphism (SNP) based on the conservative HCDiff algoritrhm. In regards to the distribution of these variations, chromosomes 10 and 2 were most affected. The novel somatic variations will be confirmed by conventional sequencing. The analyses of the remaining patients are ongoing. Using this next generation methodology, we will contribute to identify new markers or therapeutic targets and help to complete a catalogue of recurrent somatic and inherited variants associated with the development of BLBC. Keywords: Breast cancer, Basal like, BRCA1, genomic, mutation, next generation sequencing.

PENYULUHAN PENCEGAHAN KANKER PAYUDARA DI LAPAS KLAS II A PONTIANAK

Nowadays, cancers which most happened is breast cancer. The victims of this disease happened to the women. It even can cause death. However, not many people who know how to characterize these symptoms and how to face it. So, it is necessary to conduct the workshop to prevent breast cancer. Lapas Klass A II Pontianak is the prison for women. We feel they need to get the workshop about it as one of their activity in that prison to make them have new knowledge about health. So they can increase their awareness and can prevent, do early detection and treatment by themselves. This knowledge not only to themselves but also be able to help people around to avoid breast cancer occur. Keywords: Breast cancer, the prevention, workshop

Tamoxifen for Breast Cancer

Breast cancer is one of the common cancers. Hormonal therapy along with surgery, chemotherapy, radiotherapy and targeted therapy are vital modalities for the management of breast cancer. Tamoxifen has been the most widely used hormonal therapy for more than two decades. In this article we review the benefits, dose, duration and timing of Tamoxifen therapy in patients with breast cancer. Keywords: breast cancer, hormonal therapy, tamoxifen.