Oral analgesic use in postmenopausal women after curative breast cancer treatment: post hoc analysis of the ATAC trial

Aim: To evaluate analgesic use and associated conditions in postmenopausal women who had undergone curative breast cancer treatment. Materials & methods: This post hoc analysis used the Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial database, which included patient reports of concomitant medications and associated indications during follow-up. Results: Of 3434 women with eligible concomitant medication data, 71.8% reported oral analgesic use. Of 2321 patients using analgesics ≥30 days, 47.9% reported opioid use. Musculoskeletal pain was the most common indication for oral analgesic use. Of patients using opioids, 28.1% reported concomitant laxative use. Conclusion: Approximately half of the patients reported opioid use, most commonly for noncancer (musculoskeletal) pain, suggesting that breast cancer survivors experience chronic pain that should be appropriately managed.

New technique for reduction of irreducible anterior glenohumeral shoulder dislocation

Objective This study was performed to describe a new technique for reduction of anterior glenohumeral dislocation in four non-sedated patients in whom traditional techniques were unsuccessful. Methods Four patients with clinically and radiographically proven acute anterior glenohumeral dislocations were admitted to the emergency department. An oral analgesic and local infiltration of lidocaine into the glenohumeral joint were administered prior to the reduction attempts. Four to six reduction attempts using a variety of traditional maneuvers were unsuccessful before applying our technique. The glenohumeral joint was then successfully reduced using our technique and confirmed on radiographs. A sling was placed for post-reduction pain relief. Results All four patients underwent successful closed reduction, proven clinically and by radiographs, after the first attempt using our technique. No complications occurred. Conclusion Our maneuver provides safe and successful closed reduction for irreducible acute anterior glenohumeral dislocation.

Noninterventional Therapies for the Management of Knee Osteoarthritis

The goal of the practitioner managing a patient with knee osteoarthritis (OA) is to minimize pain and optimize their function. Several noninterventional (noninjectable) therapies are available for these individuals, each having varying levels of efficacy. An individualized approach to the patient is most beneficial in individuals with knee OA and the treatment plan the practitioner chooses should be based on this principle. The focus of this article is to provide an up-to-date overview of the treatment strategies available, evidence to support them, and in whom these treatments would be most appropriate. These include exercise (aerobic and resistance), weight loss, bracing and orthotics, topical and oral analgesic medications, therapeutic modalities, and oral supplements.