fatty acid turnover
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2019 ◽  
Vol 609 ◽  
pp. 133-149 ◽  
Author(s):  
L Boissonnot ◽  
B Niehoff ◽  
B Ehrenfels ◽  
JE Søreide ◽  
W Hagen ◽  
...  

2009 ◽  
Vol 185 (1-6) ◽  
pp. 351-356 ◽  
Author(s):  
Per Björntorp ◽  
Halvar Bergman ◽  
Edvardas Varnauskas

2008 ◽  
Vol 62 (4) ◽  
pp. 1530-1538 ◽  
Author(s):  
Arduino Arduini ◽  
Natalia Denisova ◽  
Ashraf Virmani ◽  
Natascia Avrova ◽  
Giorgio Federici ◽  
...  

Metabolism ◽  
2006 ◽  
Vol 55 (11) ◽  
pp. 1481-1487 ◽  
Author(s):  
Bryan C. Bergman ◽  
Dalan R. Jensen ◽  
Leslie K. Pulawa ◽  
Luis D.M.C.-B. Ferreira ◽  
Robert H. Eckel

2005 ◽  
Vol 288 (1) ◽  
pp. E155-E162 ◽  
Author(s):  
E. W. Petersen ◽  
A. L. Carey ◽  
M. Sacchetti ◽  
G. R. Steinberg ◽  
S. L. Macaulay ◽  
...  

To determine whether IL-6 increases lipolysis and fat oxidation in patients with type 2 diabetes and/or whether it exerts this effect independently of changes to the hormonal milieu, patients with type 2 diabetes (D) and healthy control subjects (CON) underwent recombinant human (rh)IL-6 infusion for 3 h. Rates of appearance (Ra) and disappearance (Rd) of [U-13C]palmitate and [6,6-2H2]glucose were determined. rhIL-6 infusion increased ( P < 0.05) palmitate Ra and Rd in a similar fashion in both groups. Neither plasma glucose concentration nor glucose Ra/Rd was affected by rhIL-6 infusion in either group, whereas rhIL-6 infusion resulted in a reduction ( P < 0.05) in circulating insulin in D. Plasma growth hormone (GH) was increased ( P < 0.05) by IL-6 in CON, and cortisol increased ( P < 0.05) in response to IL-6 in both groups. To determine whether IL-6 was exerting its effect directly or through activation of these hormones, we performed cell culture experiments. Fully differentiated 3T3-L1 adipocytes were treated with PBS (control) IL-6, or IL-6 plus dexamethasone and GH. IL-6 treatment alone increased ( P < 0.05) lipolysis, but this effect was reduced by the addition of dexamethasone and GH such that IL-6 plus dexamethasone and GH had blunted ( P < 0.05) lipolysis compared with IL-6 alone. To assess whether IL-6 increases fat oxidation, L6 myotubes were treated with PBS (Control), IL-6, or AICAR, a compound known to increase lipid oxidation. Both IL-6 and AICAR markedly increased ( P < 0.05) oxidation of [14C]palmitate compared with Control. Acute IL-6 treatment increased fatty acid turnover in D patients as well as healthy CON subjects. Moreover, IL-6 appears to be activating lipolysis independently of elevations in GH and/or cortisol and appears to be a potent catalyst for fat oxidation in muscle cells.


1997 ◽  
Vol 38 (9) ◽  
pp. 1888-1895
Author(s):  
Z Guo ◽  
S Nielsen ◽  
B Burguera ◽  
M D Jensen

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