Basaloid Squamous Carcinoma arising at Splenic Flexure of Colon

ABSTRACT Basaloid squamous carcinoma occurs most commonly in the upper aerodigestive tract. In the colon, the most common location is in the anal canal and is rarely reported proximal to the anal verge. Six cases are reported in the published literature, of which five are located distal to the splenic flexure. Outside the anal canal, it has been postulated that they arise from the basal cells, squamous metaplastic cells, or the cloacogenic embryologic cell rests. We report a case of a 57-year-old male patient who presented with short duration of abdominal pain and weight loss. Computed tomography (CT) abdomen revealed an irregular circumferential thickening in the terminal transverse colon, splenic flexure, and proximal descending colon. Colonoscopy showed a stricture in the splenic flexure, which was suspected for malignancy. Endoscopic biopsy was reported as poorly differentiated carcinoma. Left extended hemicolectomy was done, and a diagnosis of basaloid squamous carcinoma was made on histopathology. The tumor cells were positive for P63, CK 5/6; focally for CDX2; and negative for CK20, chromogranin, and CD56, confirming the histopathological diagnosis of basaloid squamous carcinoma. The patient is currently on adjuvant chemotherapy. How to cite this article Vellaisamy G, Ravikumar G, Crasta J, Rout P. Basaloid Squamous Carcinoma arising at Splenic Flexure of Colon. J Postgrad Med Edu Res 2017;51(1):33-36.

Clinicopathologic Characteristics and Clinical Outcomes of Esophageal Basaloid Squamous Carcinoma: Experience at a Single Institution

This retrospective study investigated the clinicopathologic characteristics and clinical outcomes of esophageal basaloid squamous carcinoma (BSC). Among 190 patients with esophageal carcinoma treated surgically between 1998 and 2011, we identified 9 (4.7%) with BSC. All of the patients were male, with a median age of 65 years. The frequencies of venous invasion, lymphatic invasion, and lymph node metastasis were 56%, 89%, and 67%, respectively. A total of 2 patients were pathologic stage 1, 5 were stage 2, and 2 were stage 3. Tumor recurrence was observed in 56% of the patients. The 5-year survival rate for patients with esophageal BSC was 40%, which was compatible with the figure of 53.8% for control patients (n = 18) with typical squamous cell carcinoma matched for sex, age, tumor location, and pathologic stage (P = 0.45). Although esophageal BSC shows aggressive lymph-vascular invasion and has a high likelihood of recurrence, its prognosis seems identical to that of typical squamous cell carcinoma.