Understanding the extraocular muscles: connective tissue, motor endplates and the cytoskeleton

We constantly direct our eyes to the object of interest with the help of the extraocular muscles, and thereby use foveal fixation to attain the best possible visual acuity. The muscles around the eye are rather different from other skeletal muscles, being, for example, simultaneously the fastest muscles in the body and impossible to exhaust. The most exciting property of the extraocular muscles is their unique response to disease, as they often remain unaffected in muscle conditions which lead to severe handicap and premature death. Understanding the coping strategies that allow the extraocular muscles to remain unaffected may provide clues for the future treatment of severe diseases such as muscle dystrophies.

Building the bridge between education and experience: The case for experiential learning in emergency management education

While the increasing professionalism of the Emergency Management (EM) field has brought great benefits and opportunities, increasingly the bar to entry into the profession has been on a steep incline with ever increasing mandatory and preferred requirements for EM job applicants it seems. For the EM student or new EM graduate with limited experience opportunities, this can be a severe handicap in the quest to secure a viable entry level EM position. Experiential Learning provides an excellent solution to this problem.

Presence of vestibular symptoms and related disability in migraine with and without aura and chronic migraine

Objective To assess the presence and handicap due to vestibular symptoms in three subgroups of patients with migraine and controls. Methods Women between 18–55 years old were diagnosed by headache specialists and stratified as migraine with aura (n = 60), migraine without aura (n = 60), chronic migraine (n = 60) and controls (n = 60). Information regarding demographics, headache and vestibular symptoms were collected in this cross-sectional study. The self-perceived handicap related to vestibular symptoms was assessed through the Dizziness Handicap Inventory questionnaire. Results A total of 85% of women with migraine with aura and chronic migraine had vestibular symptoms contrasted to 70% of the migraine without aura group ( p < 0.05), and 12% of the control group reported symptoms ( p < 0.0001). Patients with migraine exhibited greater Dizziness Handicap Inventory scores than controls ( p < 0.001); and migraine with aura and chronic migraine groups reached greater scores than migraine without aura ( p < 0.01). Presence of migraine is associated with a greater risk of vestibular symptoms (migraine without aura: 5.20, migraine with aura: 6.60, chronic migraine:6.20, p < 0.0003) and with a greater risk of moderate-to-severe handicap (migraine without aura: 20.0, migraine with aura: 40.0, chronic migraine: 40.0, p < 0.0003). The presence of aura and greater migraine frequency adds to the risk of any handicap (migraine with aura: 1.9, chronic migraine: 1.7, p < 0.04) and to the risk of moderate-to-severe handicap (migraine with aura: 2.0, chronic migraine: 2.0, p < 0.0003). Migraine aura, intensity and frequency predict 36% of the dizziness handicap. Conclusion The prevalence of vestibular symptoms is increased in migraine during and between headache attacks, particularly in migraine with aura and chronic migraine along with an increased handicap due to those symptoms. Vestibular symptoms among subgroups of migraine should be considered when evaluating the functional impact of migraine.

Unavailability: When Neighbors Become Strangers

Richard Kearney’s Anatheism: Returning to God After God has hospitality to the stranger as one of its central features. This article traces the roots of such hospitality back through Kearney’s mentor Paul Ricoeur to Ricoeur’s own mentor, Gabriel Marcel. Marcel’s analysis of the role of abstraction in philosophical reflection leads him to propose a réflexion seconde as a means of avoiding the lure of the “spirit of abstraction.” Necessary to second reflection is the cultivation of the virtue Marcel calls “availability,” and it is in light of this elemental, though often elusive, ground for thinking and living that even the best ambitions of the hospitable wager are put to a strenuous test. The second part of the article takes up the case of post-Katrina New Orleans as a way of showing that in a consumerist and calculative society there is a default resistance to availability and therefore a severe handicap to entering even the most basic scene of hospitality. The intractable lack of availability thus rivals the otherwise provocative summons to the threshold of welcome, even where it concerns the neighbor. The anatheistic wager, though profound in its own right, will rarely be undertaken, and “available” inquiry thus faces a more elemental initial task.

OBSERVATIONS ON MONEY, BARTER AND BOOKKEEPING

Britain forbade her 18th-century American colonies to set up mints, and sent no supplies of her own coins. In consequence, the colonies were without any official money. Account books of the period reveal how traders fared in this unusual situation. They show that the lack of money was a severe handicap that hindered and distorted trade, but that the colonists to some extent overcame it with the aid of ingenious ledger entries. These culminated in payment by credit transfers in the books of third parties. Such transactions lead to a discussion of the nature of money.

Comparing Performance of Pupils with High Spatial-Low Numerical and High Numerical-Low Spatial Scores on a Standardized Mathematics Test in the United Kingdom

Questions from a national mathematics test taken by over a 1,000 12- and 13-yr.-olds in the United Kingdom were perused for heavily loaded spatial and numerical items. Pupils' answers to the two types of item were examined, and those who answered well in one of the categories but poorly in the other were selected to form two groups, those high in spatial thinking but low in numerical thinking and those high in numerical thinking but low in spatial thinking to assess whether the approaches to solve the item used by each group were different. The two groups did indeed utilize different thinking strategies to solve the questions. For example, questions involving angle and volume, items thought to require a high spatial facility, were answered correctly by the predominantly numerical thinkers as often as by the predominantly spatial thinkers. This would indicate that one of the samples, i.e., numerical thinkers, used a different strategy than the other, i.e., spatial thinkers. This was verified by examination of students' work in the test booklets and personal interviews of them. Also, the same proportion of boys in each group was recorded, but a higher percentage of girls was recorded in the spatial group than in the numerical. This reflected the large number of boys who scored high on the spatial measures also doing moderately well on the numerical items and so, being moved out of the solely spatial group. Since the tests used by mathematics educators to assess learning are so heavily laden with linguistic/analytical rather than holistic/spatial types of questions, pupils high in spatial but low in numerical thinking face a severe handicap in schools.