Predominant Endotype of Nasal Polyps in a Sample of Filipinos Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis with Nasal Polyposis

ABSTRACT Objective: To determine the prevalence of eosinophilic and non-eosinophilic nasal polyps in Filipino patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) who underwent endoscopic sinus surgery. Methods: Design: Retrospective Chart Review Setting: Tertiary Government Training Hospital Participants: A consecutive sample of adult patients who underwent endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis at the Rizal Medical Center from 2015-2019. Results: Out of 66 patients who underwent endoscopic sinus surgery during the study period, 36 (54.55%) had an eosinophilic endotype while 30 (45.45%) had a non-eosinophilic endotype. Conclusion: he slight predominance of eosinophilic nasal polyps found in our sample may suggest a contrasting trend compared to our Asian neighbors, who have a predominantly non[1]eosinophilic endotype – Indonesia (90.47%), Thailand (81.9%), South Korea (66.7%) and China (53.6%). However, this predominance is still lower than the 78-88% eosinophilia reported among Caucasians. Larger series may confirm these preliminary findings

Improvements in Hearing and in Quality of Life after Sequential Bilateral Cochlear Implantation in a Consecutive Sample of Adult Patients with Severe-to-Profound Hearing Loss

Bilateral cochlear implantation is increasing worldwide. In adults, bilateral cochlear implants (BICI) are often performed sequentially with a time delay between the first (CI1) and the second (CI2) implant. The benefits of BICI have been reported for well over a decade. This study aimed at investigating these benefits for a consecutive sample of adult patients. Improvements in speech-in-noise recognition after CI2 were followed up longitudinally for 12 months with the internationally comparable Finnish matrix sentence test. The test scores were statistically significantly better for BICI than for either CI alone in all assessments during the 12-month period. At the end of the follow-up period, the bilateral benefit for co-located speech and noise was 1.4 dB over CI1 and 1.7 dB over CI2, and when the noise was moved from the front to 90 degrees on the side, spatial release from masking amounted to an improvement of 2.5 dB in signal-to-noise ratio. To assess subjective improvements in hearing and in quality of life, two questionnaires were used. Both questionnaires revealed statistically significant improvements due to CI2 and BICI. The association between speech recognition in noise and background factors (duration of hearing loss/deafness, time between implants) or subjective improvements was markedly smaller than what has been previously reported on sequential BICI in adults. Despite the relatively heterogeneous sample, BICI improved hearing and quality of life.

Limb Salvage in Diabetic Patients With Ischemic Heel Ulcers

The purpose of this study is to investigate the outcomes of diabetic individuals with ischemic heel ulcers. The study group was composed of a consecutive sample of persons with diabetic ischemic foot ulcers managed by a preset multidisciplinary limb salvage protocol, including revascularization through endovascular technique. The outcome measures were healing, major amputation (above the ankle), and death at 1-year of follow-up. The outcomes between patients with heel ulcers (HUs) and without (NHUs) were compared. A total of 254 patients were recruited. There were 50/254 (19.7%) HUs and 204/254 (79.3%) NHUs. Overall, 190/254 (74.8%) patients healed. The rate of healing for HUs and NHUs was 30/50 (60%) and 160/204 (78.4%); P = .03, respectively. Major amputation occurred in 24/254 (9.4%) patients. The rates of major amputation for HUs and NHUs were 10/50 (20%) and 14/204 (6.9%; P = .002), respectively; 40/254 (15.7%) patients died, unhealed. The rates of mortality for HUs and NHUs were 10/50 (20%) and 30/204 (14.7%; P = .07), respectively. In HUs patients, absence of infection [95% CI = 3.1 (1.6-5.5); P = .002] and superficial ulcers [95% CI = 4.4 (2.2-9.3); P = .0001] were independent predictors of healing, whereas revascularization failure [95% CI = 8.1 (1.5.0-19.4); P = .0001], involvement of the plantar arch [95% CI = 6.3 (2.0-15.4); P = .0001], and dialysis [95% CI = 2.2 (1.3-4.5); P = .006] were independent predictors of major amputation. A multidisciplinary approach achieves good rate of limb salvage in people with diabetic ischemic heel ulcers.

Hubungan Harga Diri dengan Perilaku Seksual pada Penderita HIV AIDS di Kabupaten Indramayu

ABSTRAK Masalah HIV dan AIDS adalah masalah kesehatan masyarakat yang memerlukan perhatian serius. Hal ini karena kasus HIV/AIDS yang dilaporkan setiap tahunnya selalu meningkat secara signifikan. Mayoritas infeksi HIV berasal dari hubungan seksual tanpa pelindung antar individu yang salah satunya terkena HIV. Belum ditemukannya obat untuk mengobati HIV/AIDS menyebabkan orang dengan HIV AIDS (ODHA) akan mengalami perubahanpsikologis, salah satunya adalah harga diri rendah. Hal ini disebabkan karena stigma yang negatif dari masyarakat terhadap ODHA. Respon terhadap harga diri tersebut tidak menutup kemungkinan melakukan upaya untuk menularkan penyakitnya kepada orang lain. Hal ini dapat diwujudkan dengan perilaku seksual yang tidak baik. Desain penelitian adalah deskriptif analitik dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah penderita HIV AIDS yang melakukan pengobatan rutin di unit pelayanan HIV AIDS RSUD Indramayu dan RS Bhayangkara Indramayu. Teknik pengambilan sampel consecutive sample. Jumlah sampel sebanyak 125 orang. Alat pengumpul data berupa quesionare untuk mengukur harga diri dan perilaku seksual. Uji statistik menggunakan uji chi-square. Hasil penelitian didapatkan sebanyak 64 responden memiliki harga diri tinggi (51,20%), sebanyak 94 responden memiliki perilaku seksual berisiko (75,20%). Hasil uji chi square didapatkan p value 1,00 sehingga dapat disimpulkan tidak ada hubungan antara harga diri dengan perilaku seksual penderita HIV AIDS di Kabupaten Indramayu Tahun 2015 (nilai α=0,05; CI 95%). Perilaku seksual penderita HIV AIDS tidak dipengaruhi oleh harga diri, namun dipengaruhi oleh faktor lain. ABSTRACT The issue of HIV and AIDS is a public health issue that needs serious attention. This is because the reported cases of HIV / AIDS always increase significantly each year. The majority of HIV infections come from unprotected sexual intercourse among individuals one of whom is suffered from HIV. The absence of drugs to treat HIV/AIDS causes HIV AIDS (ODHA) patients experience psychological changes, one of which is low self-esteem. This is due to the negative stigma of the community towards people living with HIV. One of the responses to the self-esteem is try to transmit the disease to others. This can be manifested by bad sexual behavior. The design of the research is analytical descriptive with cross sectional approach. The sample of the study is HIV/AIDS patients who perform routine treatment at HIV/AIDS service unit of RSUD Indramayu and Bhayangkara Indramayu Hospital. technique sampling of the study is Consecutive sample. The samples are 125 people. Data collection instruments are questionare to measure self-esteem and sexual behavior. The chi-square test used to do statistical test. The result of the research shows that 64 respondents have high self esteem (51,20%), 94 respondents have risky sexual behavior (75,20%). Chi square test results p value 1.00 so it can be concluded there is no relation between self-esteem with sexual behavior of HIV AIDS patient in Indramayu Regency Year 2015 (value α = 0,05; 95% CI). Sexual behavior of HIV AIDS patient is not influenced by self-esteem, but influenced by other factors. Keywords: self-esteem, sexual behavior, HIV AIDS patient