Human visual motion perception shows hallmarks of Bayesian structural inference

Motion relations in visual scenes carry an abundance of behaviorally relevant information, but little is known about how humans identify the structure underlying a scene’s motion in the first place. We studied the computations governing human motion structure identification in two psychophysics experiments and found that perception of motion relations showed hallmarks of Bayesian structural inference. At the heart of our research lies a tractable task design that enabled us to reveal the signatures of probabilistic reasoning about latent structure. We found that a choice model based on the task’s Bayesian ideal observer accurately matched many facets of human structural inference, including task performance, perceptual error patterns, single-trial responses, participant-specific differences, and subjective decision confidence—especially, when motion scenes were ambiguous and when object motion was hierarchically nested within other moving reference frames. Our work can guide future neuroscience experiments to reveal the neural mechanisms underlying higher-level visual motion perception.

Human visual motion perception shows hallmarks of Bayesian structural inference

Motion relations in visual scenes carry an abundance of behaviorally relevant information, but little is known about the computations underlying the identification of visual motion structure by humans. We addressed this gap in two psychophysics experiments and found that participants identified hierarchically organized motion relations in close correspondence with Bayesian structural inference. We demonstrate that, for our tasks, a choice model based on the Bayesian ideal observer can accurately match many facets of human structural inference, including task performance, perceptual error patterns, single-trial responses, participant-specific differences, and subjective decision confidence, particularly when motion scenes are ambiguous. Our work can guide future neuroscience experiments to reveal the neural mechanisms underlying higher-level visual motion perception.

Bayesian Estimation of 3D Chromosomal Structure from Single Cell Hi-C Data

The problem of 3D chromosome structure inference from Hi-C datasets is important and challenging. While bulk Hi-C datasets contain contact information derived from millions of cells, and can capture major structural features shared by the majority of cells in the sample, they do not provide information about local variability between cells. Single cell Hi-C can overcome this problem, but contact matrices are generally very sparse, making structural inference more problematic. We have developed a Bayesian multiscale approach, named SIMBA3D, to infer 3D structures of chromosomes from single cell Hi-C while including the bulk Hi-C data and some regularization terms as a prior. We study the landscape of solutions for each single-cell Hi-C dataset as a function of prior strength and demonstrate clustering of solutions using data from the same cell.