Gingival Tumor in Young Female Patient: A Case Report

Pyogenic granuloma is one of the inflammatory hyperplasias seen in the oral cavity. This term is a misnomer because the lesion is unrelated to infection and in reality arises in response to various stimuli such as low-grade local irritation, traumatic injury or hormonal factors. Clinically, oral pyogenic granuloma is a smooth or lobulated exophytic lesion manifesting as small, red erythematous papules on a pedunculated or sometimes sessile base, which is usually hemorrhagic. The surface ranges from pink to red to purple, depending on the age of the lesion Conservative surgical excision is usually curative but recurrence is not unusual. Lasers and cryotherapy may also be employed.

Dental Management of Peripheral Giant Cell Granuloma in an 8-Year-Old Boy: A Case Report

Background: Peripheral giant cell granuloma (PGCG) or the so-called giant cell epulis is the most common oral giant cell lesion. It normally appears as a soft tissue purple-red nodule. This lesion is certainly not a true neoplasm, but in nature, it may be reactive, thought to be stimulated by local irritation or trauma. Nonetheless, the exact cause is definitely not understood well. In appearance, lesions vary from smooth, uniformly outlined masses to irregularly developed, multilobed surface indentation protuberances. Margin ulcerations are occasionally observed as well. The lesions are painless, differ in size, and can cover many teeth. It may be a lesion on the gingiva or alveolar crest that is sessile or pedunculated, common with respect to the molars and incisors and occurs in reaction to the local response.

Surgical Removal of a Focal Fibrous Hyperplasia: Two Case Reports

Focal fibrous hyperplasia is the most common epithelial benign tumor of the oral cavity. It is a localized reactive progressive, proliferation of oral mucosa in response to injury or local irritation. Females are twice more likely to develop fibroma than male. Surgical excision is performed and histological examination of the excised specimen and definitive diagnosis was obtained. This paper reports two cases of focal fibrous hyperplasia in both maxillary and mandibular locations.

ВИБІР СКЛАДУ БУФЕРНОЇ СИСТЕМИ ДЛЯ ОЧНИХ КРАПЕЛЬ З ТЕТРАГІДРОЗОЛІНУ ГІДРОХЛОРИДОМ

The purpose of this article is developing the optimal formulation of excipients for eye drops with tetrahydrosoline hydrochloride and researching of the locally irritating effect of the selected formulation of eye drops. The objects of the research are experimental solutions of eye drops with tetrahydrosoline hydrochloride using different combinations of excipients. Evaluation of test results in the selection of the formulation was performed according to the physico-chemical parameters of the prepared eye drops solution along with researching of stability. Assessment of the local irritation was performed on Chinchilla rabbits, particularly on the mucous membrane of the rabbit’s eye. The optimal formulation of the eye drops with tetrahydrozoline hydrochloride of a medicinal product using citrate buffer solution was developed. The result solution represents a clear homogeneous aqueous solution to physical and chemical properties. The developed formulation contains (in grams): tetrahydrozoline hydrochloride - 0.05; benzalkonium chloride - 0.01; disodium edetate - 0.01; sodium chloride - 0.84; citrate buffer - to a pH of 6.2 to 6.5; injection water - up to 100 ml. Samples of the experimental series of eye drops meet the requirements of HFC on ophthalmic drugs in terms of physico-chemical quality indicators as description, transparency, osmolality, pH of the solution, quantitative content of tetrahydrazoline hydrochloride. The results obtained in the research of stability of the eye drops experimental series throughout a long-term and accelerated storage during 6-months observation indicate the invariance of critical quality indicators, such as description, transparency, pH of the solution and the quantitative content of tetrahydrazoline hydrochloride. The results of determining the locally irritant effect on the mucous membrane of the rabbit’s eye showed that developed formulation of the eye drops does not cause any local irritation, neither visual reaction from the mucous membrane of the eye. The damaging effect level was 0 points in comparison with the other drugs. It is proved that the proposed formulation of eye drops meets the requirements of SPhU, stable and comfortable to use. The results of this experiment have a practical importance for development of new generic drugs.

Comparison of Safety and Efficacy of Potassium Hydroxide versus Combination of Salicylic and Lactic Acid for Molluscum Contagiosum

Background: Molluscum contagiosum (MC) is a contagious cutaneous infection caused by MC virus, affecting mainly the pediatric population. It is characterized by flesh-colored umbilicated papules occurring on the skin surface. Potassium hydroxide (KOH) and salicylic acid plus lactic acid combination being keratolytic agents, are effective treatment options. The objective of the study was to compare the efficacy and safety of 10% KOH solution versus salicylic acid/ lactic acid combination in treating Molluscum contagiosum in pediatric population. Material and Methods: A total of 80 children (age range 1-13 years) with Molluscum contagiosum lesions were selected from the Dermatology Out-Patient Department, and were randomly allocated into two groups by lottery method. Group A was given topical 10% KOH solution and group B was given Salicylic plus Lactic acid preparations for topical application. Patients were followed after two weeks to see regression in size of the lesion, and development of any side-effects. Final visit was scheduled at 6 weeks. Statistical analysis was carried out using SPSS (version 16) with p value less than 0.05 considered as statistically significant. Results: Patients with MC (n = 80) were equally divided into group A (treated with 10% KOH) and group B (treated with combination of Salicylic acid and Lactic acid). After 6 weeks, complete remission from Molluscum contagiosum virus was seen in 29 (72.5%) patients of group A and 34 (85%) patients of group B. There were 12 (30%) patients in group A who developed local irritation and 4 (10%) developed local erythema after 6 weeks. None of the patients of group B had any such side effects. Conclusion: 10% KOH solution is as effective as the combination of Salicylic and Lactic acids for treatment of Molluscum contagiosum in pediatric population, however it is associated with side effects of local irritation and erythema.