Organo-Redox-Catalysis for the difunctionalization of alkenes and oxidative Ritter reactions by C-H functionalization

Transition metals are the dominant catalysts for redox-reactions between peroxides and organic substrates. Here, we show that triarylamines can act as organic redox-catalysts, enabling oxidative difunctionalization reactions of alkenes and...

Synthesis and Biological Evaluation of Furo[3,2-c]pyrazole-5-carbimidates

In the present work, novel pyrazole fused dihydrofurans synthesized via a chronological addition of N-chloro succinimide and base piperidine to pyrano[3,2-c]pyrazole carbonitrile derivatives in methanol medium. Oxidative difunctionalization was done with the reagent N-chloro succinimide by the addition of both chlorine and alkoxy groups crosswise the chromene double bond. The addition of base results in the construction of dihydrofuran derivatives by ring contraction. The structures of newly synthesized compounds were characterized on the basis of physical and spectral data. Synthesized compounds were evaluated for antibacterial and anti-inflammatory activities. All the compounds exhibited significant antibacterial activity against all the four strains of bacteria and their MICs ranged between 1.56 and 12.55 μg/mL. In anti-inflammatory screening, among all the tested compounds, compounds 7, 8, 9, 11, 12, 13, 14, 16, 17 and 18 exhibited significant protection against the edema formation at a concentration of 100 mg/kg.

Retraction: Visible-light-induced oxidative difunctionalization of styrenes: synthesis of α-trifluoromethylthio-substituted ketones

Retraction of ‘Visible-light-induced oxidative difunctionalization of styrenes: synthesis of α-trifluoromethylthio-substituted ketones’ by Arvind Kumar Yadav et al., Chem. Commun., 2018, 54, 1976–1979.

Retracted Article: Visible-light-induced oxidative difunctionalization of styrenes: synthesis of α-trifluoromethylthio-substituted ketones

Synthesis of α-trifluoromethylthio-substituted ketones has been accomplished through photoredox catalysis from easily accessible styrenes. The present approach involves the use of inexpensive eosin Y as an organophotoredox catalyst and a CF3SO2Na/CS2 blend as a new source of SCF3 radicals at room temperature.