peripheral spectrum
Recently Published Documents


TOTAL DOCUMENTS

26
(FIVE YEARS 1)

H-INDEX

7
(FIVE YEARS 0)

2021 ◽  
Vol 92 ◽  
pp. 104855
Author(s):  
Paulin Sonon ◽  
Cristhianna V.A. Collares ◽  
Maria Lúcia Brito Ferreira ◽  
Renata Santos Almeida ◽  
Ibrahim Sadissou ◽  
...  

Positivity ◽  
2018 ◽  
Vol 22 (4) ◽  
pp. 931-968
Author(s):  
Egor A. Alekhno

Positivity ◽  
2015 ◽  
Vol 20 (2) ◽  
pp. 307-336 ◽  
Author(s):  
Jochen Glück

2015 ◽  
Vol 31 (6) ◽  
pp. 953-972 ◽  
Author(s):  
Wen Zhang ◽  
Jin Chuan Hou ◽  
Xiao Fei Qi

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Carlos Abrantes ◽  
Rui Caetano Oliveira ◽  
Joana Saraiva ◽  
João Bernardo ◽  
Lina Carvalho

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) and tumorlets are neuroendocrine cells proliferations smaller than 5 mm. The former confines to bronchial/bronchiolar wall, while the latter broke through epithelial basement membrane. The authors present 3 cases of DIPNECH and tumorlets associated with a typical peripheral carcinoid tumor without underlying lung disease. The patients presented with nonspecific pulmonary symptoms: 3 females, 60, 72, and 84 years old, whose CT-scans showed well-defined pulmonary nodules, 2.2, 1.6, and 1.4 cm, respectively; first patient was submitted to lobectomy and the others underwent surgical biopsy. Whitish/brownish lobulated tumors corresponded to typical carcinoids (less than 2 mitoses/2 mm2and without necrosis); polygonal/elongated cells under lobular pattern expressed CD56, chromogranin A, synaptophysin, and CK7; Ki-67 positivity was between 1 and 3%. Bronchial/bronchiolar wall neuroendocrine cell hyperplasia and several neuroendocrine nodules under 5 mm, with identical morphologic and immunoexpression, were observed, without lung disease. Typical carcinoid associated with DIPNECH and tumorlets without other pulmonary diseases is rare. Sporadic cases may recall embryonal neuroendocrine differentiation potentiality to develop peripheral hyperplasia, most commonly in underoxygenated parenchyma. The described cases are elucidative of peripheral spectrum of neuroendocrine cell tumour evolution, reinforcing higher female incidence as in central carcinoids, still without a clear preneoplastic lesion.


Sign in / Sign up

Export Citation Format

Share Document