cdc25 protein
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Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 513
Author(s):  
Boyang Liu ◽  
Han Zhao ◽  
Keliang Wu ◽  
Jörg Großhans

Cell proliferation in early embryos by rapid cell cycles and its abrupt pause after a stereotypic number of divisions present an attractive system to study the timing mechanism in general and its coordination with developmental progression. In animals with large eggs, such as Xenopus, zebrafish, or Drosophila, 11–13 very fast and synchronous cycles are followed by a pause or slowdown of the cell cycle. The stage when the cell cycle is remodeled falls together with changes in cell behavior and activation of the zygotic genome and is often referred to as mid-blastula transition. The number of fast embryonic cell cycles represents a clear and binary readout of timing. Several factors controlling the cell cycle undergo dynamics and gradual changes in activity or concentration and thus may serve as temporal gradients. Recent studies have revealed that the gradual loss of Cdc25 protein, gradual depletion of free deoxyribonucleotide metabolites, or gradual depletion of free histone proteins impinge on Cdk1 activity in a threshold-like manner. In this review, we will highlight with a focus on Drosophila studies our current understanding and recent findings on the generation and readout of these temporal gradients, as well as their position within the regulatory network of the embryonic cell cycle.


PLoS Genetics ◽  
2020 ◽  
Vol 16 (4) ◽  
pp. e1008735
Author(s):  
Boyang Liu ◽  
Ingo Gregor ◽  
H.-Arno Müller ◽  
Jörg Großhans

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Tie-Zhong Cui ◽  
Tabitha A Peterson ◽  
Christopher G Burd

We describe a regulatory mechanism that controls the activity of retromer, an evolutionarily conserved sorting device that orchestrates cargo export from the endosome. A spontaneously arising mutation that activates the yeast (Saccharomyces cerevisiae) CDC25 family phosphatase, Mih1, results in accelerated turnover of a subset of endocytosed plasma membrane proteins due to deficient sorting into a retromer-mediated recycling pathway. Mih1 directly modulates the phosphorylation state of the Vps26 retromer subunit; mutations engineered to mimic these states modulate the binding affinities of Vps26 for a retromer cargo, resulting in corresponding changes in cargo sorting at the endosome. The results suggest that a phosphorylation-based gating mechanism controls cargo selection by yeast retromer, and they establish a functional precedent for CDC25 protein phosphatases that lies outside of their canonical role in regulating cell cycle progression.


2009 ◽  
Vol 92 (6) ◽  
pp. 1997-2003 ◽  
Author(s):  
Hsien-An Pan ◽  
Yeu-Chin Lee ◽  
Yen-Ni Teng ◽  
Shaw-Jeng Tsai ◽  
Yung-Ming Lin ◽  
...  

2007 ◽  
Vol 7 (8) ◽  
pp. 1270-1275 ◽  
Author(s):  
Chiara Paiardi ◽  
Fiorella Belotti ◽  
Sonia Colombo ◽  
Rentata Tisi ◽  
Enzo Martegani

2001 ◽  
Vol 12 (12) ◽  
pp. 3892-3903 ◽  
Author(s):  
Ivan Rupes̆ ◽  
Bradley A. Webb ◽  
Alan Mak ◽  
Paul G. Young

In budding yeast, actin disruption prevents nuclear division. This has been explained as activation of a morphogenesis checkpoint monitoring the integrity of the actin cytoskeleton. The checkpoint operates through inhibitory tyrosine phosphorylation of Cdc28, the budding yeast Cdc2 homolog. Wild-type Schizosaccharomyces pombe cells also arrest before mitosis after actin depolymerization. Oversized cells, however, enter mitosis uninhibited. We carried out a careful analysis of the kinetics of mitotic initiation after actin disruption in undersized and oversized cells. We show that an inability to reach the mitotic size threshold explains the arrest in smaller cells. Among the regulators that control the level of the inhibitory Cdc2-Tyr15 phosphorylation, the Cdc25 protein tyrosine phosphatase is required to link cell size monitoring to mitotic control. This represents a novel function of the Cdc25 phosphatase. Furthermore, we demonstrate that this cell size-monitoring system fulfills the formal criteria of a cell cycle checkpoint.


2001 ◽  
Vol 66 (22) ◽  
pp. 7263-7269 ◽  
Author(s):  
Stéphane Poigny ◽  
Samia Nouri ◽  
Angèle Chiaroni ◽  
Michèle Guyot ◽  
Mohammad Samadi

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