artificial receptor
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Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6919
Author(s):  
Zhe Liu ◽  
Ying Ye ◽  
Hong Wang ◽  
Li-xia Luo

Chiral cholesteric molecular tweezer 7a was synthesized, and its recognition properties for Ag+, Al3+, Ca2+ etc., were investigated by UV and fluorescence spectra. The results showed that in ethanol/Tris (1/1, v/v, pH 7.0) buffer solution, the host molecular tweezer 7a had a specific recognition ability for Ag+, the detection limit was up to 1 × 10−6 mol/L, and other metal ions had little effect on Ag+ recognition. At the same time, the naked-eye detection of Ag+ was realized by the light red color of the complex solution. Furthermore, the mechanism of recognition of Ag+ by molecular tweezer 7a was studied by a nuclear magnetic titration test and computer molecular simulation, and a rapid detection method of Ag+ using host molecular tweezer 7a was established. Through the determination of Ag+ in milk powder, quinoa and other food samples, it was proved that this novel method had a good application prospect for the detection of Ag+ in food.


RSC Advances ◽  
2021 ◽  
Vol 11 (36) ◽  
pp. 22221-22229
Author(s):  
Linda Köhler ◽  
Conrad Hübler ◽  
Wilhelm Seichter ◽  
Monika Mazik

Complexes formed between methyl α-d-glucopyranoside and an artificial receptor represent a valuable source of information about the basic molecular features of carbohydrate recognition.


iScience ◽  
2020 ◽  
Vol 23 (12) ◽  
pp. 101750
Author(s):  
Hoda Safari Yazd ◽  
Yu Yang ◽  
Long Li ◽  
Lu Yang ◽  
Xiaowei Li ◽  
...  

2020 ◽  
Vol MA2020-02 (44) ◽  
pp. 2821-2821
Author(s):  
Yusuke Murai ◽  
Takesi Ikeda ◽  
Takenori Isida ◽  
Ryuichi Hirota ◽  
Akio Kuroda ◽  
...  

2020 ◽  
Vol MA2020-02 (44) ◽  
pp. 2829-2829
Author(s):  
Hisakage Funabashi ◽  
Hajime Shigeto
Keyword(s):  

Science ◽  
2020 ◽  
Vol 370 (6519) ◽  
pp. 961-965 ◽  
Author(s):  
Insang You ◽  
David G. Mackanic ◽  
Naoji Matsuhisa ◽  
Jiheong Kang ◽  
Jimin Kwon ◽  
...  

Human skin has different types of tactile receptors that can distinguish various mechanical stimuli from temperature. We present a deformable artificial multimodal ionic receptor that can differentiate thermal and mechanical information without signal interference. Two variables are derived from the analysis of the ion relaxation dynamics: the charge relaxation time as a strain-insensitive intrinsic variable to measure absolute temperature and the normalized capacitance as a temperature-insensitive extrinsic variable to measure strain. The artificial receptor with a simple electrode-electrolyte-electrode structure simultaneously detects temperature and strain by measuring the variables at only two measurement frequencies. The human skin–like multimodal receptor array, called multimodal ion-electronic skin (IEM-skin), provides real-time force directions and strain profiles in various tactile motions (shear, pinch, spread, torsion, and so on).


2020 ◽  
Vol 20 (22) ◽  
pp. 1993-1998
Author(s):  
Renuka Suravajhala ◽  
Harshavardhan Reddy Burri ◽  
Babita Malik

Artificial receptor-like structures such as molecular imprinted polymers (MIPs) are biomimetic molecules are used to replicate target specific antibody-antigen mechanism. In MIPs, selective binding of template molecule can be significantly correlated with lock and key mechanism, which play a major role in the drug delivery mechanism. The MIPs are biocompatible with high efficiency and are considered in several drug delivery and biosensor applications besides continuous and controlled drug release leading to better therapeutics. There is a need to explore the potential synthetic methods to improve MIPs with respect to the imprinting capacity in cancer therapeutics. In this review, we focus on MIPs as drug delivery mechanism in cancer and the challenges related to their synthesis and applications.


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