anthropoid primate
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Science ◽  
2020 ◽  
Vol 368 (6487) ◽  
pp. 194-197 ◽  
Author(s):  
Erik R. Seiffert ◽  
Marcelo F. Tejedor ◽  
John G. Fleagle ◽  
Nelson M. Novo ◽  
Fanny M. Cornejo ◽  
...  

Phylogenetic evidence suggests that platyrrhine (or New World) monkeys and caviomorph rodents of the Western Hemisphere derive from source groups from the Eocene of Afro-Arabia, a landmass that was ~1500 to 2000 kilometers east of South America during the late Paleogene. Here, we report evidence for a third mammalian lineage of African origin in the Paleogene of South America—a newly discovered genus and species of parapithecid anthropoid primate from Santa Rosa in Amazonian Perú. Bayesian clock–based phylogenetic analysis nests this genus (Ucayalipithecus) deep within the otherwise Afro-Arabian clade Parapithecoidea and indicates that transatlantic rafting of the lineage leading to Ucayalipithecus likely took place between ~35 and ~32 million years ago, a dispersal window that includes the major worldwide drop in sea level that occurred near the Eocene-Oligocene boundary.


2019 ◽  
Vol 26 (2) ◽  
pp. C1-C5
Author(s):  
Jonathan W Nyce

We recently reported our detection of an anthropoid primate-specific, ‘kill switch’ tumor suppression system that reached its greatest expression in humans, but that is fully functional only during the first twenty-five years of life, corresponding to the primitive human lifespan that has characterized the majority of our species' existence. This tumor suppression system is based upon the kill switch being triggered in cells in which p53 has been inactivated; such kill switch consisting of a rapid, catastrophic increase in ROS caused by the induction of irreversible uncompetitive inhibition of glucose-6- phosphate dehydrogenase (G6PD), which requires high concentrations of both inhibitor (DHEA) and G6P substrate. While high concentrations of intracellular DHEA are readily available in primates from the importation and subsequent de-sulfation of circulating DHEAS into p53-affected cells, both an anthropoid primate-specific sequence motif (GAAT) in the glucose-6-phosphatase (G6PC) promoter, and primate-specific inactivation of de novo synthesis of vitamin C by deletion of gulonolactone oxidase (GLO) were required to enable accumulation of G6P to levels sufficient to enable irreversible uncompetitive inhibition of G6PD. Malignant transformation acts as a counterforce opposing vertebrate speciation, particularly increases in body size and lifespan that enable optimized exploitation of particular niches. Unique mechanisms of tumor suppression that evolved to enable niche exploitation distinguish vertebrate species, and prevent one vertebrate species from serving as a valid model system for another. This here-to-fore unrecognized element of speciation undermines decades of cancer research data, using murine species, which presumed universal mechanisms of tumor suppression, independent of species. Despite this setback, the potential for pharmacological reconstitution of the kill switch tumor suppression system that distinguishes our species suggests that ‘normalization’ of human cancer risk, from its current 40% to the 4% of virtually all other large, long-lived species, represents a realistic near-term goal.


PLoS Biology ◽  
2018 ◽  
Vol 16 (9) ◽  
pp. e2006337 ◽  
Author(s):  
Caitlin E. Dunn-Fletcher ◽  
Lisa M. Muglia ◽  
Mihaela Pavlicev ◽  
Gernot Wolf ◽  
Ming-An Sun ◽  
...  

2017 ◽  
Vol 8 (2) ◽  
pp. 1206-1216 ◽  
Author(s):  
Carlos G. Schrago ◽  
Beatriz Mello ◽  
Anieli G. Pereira ◽  
Carolina Furtado ◽  
Hector N. Seuánez

2016 ◽  
Vol 3 (9) ◽  
pp. 160288 ◽  
Author(s):  
R. I. M. Dunbar ◽  
Ben Teasdale ◽  
Jackie Thompson ◽  
Felix Budelmann ◽  
Sophie Duncan ◽  
...  

Fiction, whether in the form of storytelling or plays, has a particular attraction for us: we repeatedly return to it and are willing to invest money and time in doing so. Why this is so is an evolutionary enigma that has been surprisingly underexplored. We hypothesize that emotionally arousing drama, in particular, triggers the same neurobiological mechanism (the endorphin system, reflected in increased pain thresholds) that underpins anthropoid primate and human social bonding. We show that, compared to subjects who watch an emotionally neutral film, subjects who watch an emotionally arousing film have increased pain thresholds and an increased sense of group bonding.


2012 ◽  
Vol 25 (5) ◽  
pp. 981-994 ◽  
Author(s):  
A. M. BODDY ◽  
M. R. McGOWEN ◽  
C. C. SHERWOOD ◽  
L. I. GROSSMAN ◽  
M. GOODMAN ◽  
...  

2012 ◽  
Vol 136 (4) ◽  
pp. 278-287 ◽  
Author(s):  
E. Schneider ◽  
S. Mayer ◽  
N. El Hajj ◽  
L.R. Jensen ◽  
A.W. Kuss ◽  
...  

2009 ◽  
Vol 75 (11) ◽  
pp. 3796-3799 ◽  
Author(s):  
Takema Fukatsu ◽  
Takahiro Hosokawa ◽  
Ryuichi Koga ◽  
Naruo Nikoh ◽  
Takuya Kato ◽  
...  

ABSTRACT A symbiotic bacterium of the macaque louse, Pedicinus obtusus, was characterized. The symbiont constituted a gammaproteobacterial lineage distinct from the symbionts of anthropoid primate lice, localized in the midgut epithelium and the ovaries and exhibiting AT-biased genes and accelerated molecular evolution. The designation “Candidatus Puchtella pedicinophila” was proposed for it.


Author(s):  
Lauren A. Milligan ◽  
Stanley I. Rapoport ◽  
Michael R. Cranfield ◽  
Wolfgang Dittus ◽  
Kenneth E. Glander ◽  
...  

2007 ◽  
Vol 53 (3) ◽  
pp. 292-301 ◽  
Author(s):  
Anthony J. Olejniczak ◽  
Christopher C. Gilbert ◽  
Lawrence B. Martin ◽  
Tanya M. Smith ◽  
Lilian Ulhaas ◽  
...  

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