Serum chromium, glycosylated hemoglobin level and body mass index among control and uncontrol sudanese patients with type II diabetes mellitus: Correlation study

Background: Chromium is an essential micronutrient which is required for the normal functioning of insulin and regulation of blood sugar levels. It acts as a vital antioxidant for maintaining insulin homeostasis. In diabetes mellitus, the free radical production is increased and levels of antioxidants like chromium, vanadium, selenium and manganese are reduced. Aim: To study the level of serum chromium level in patients with type 2 diabetes mellitus and its association with glycemic control. Materials and Methods: One hundred and twenty individuals were enrolled in this study, classified into 60 type II diabetes mellitus (type II DM) patients and 60 apparently health as control group. Serum chromium and Glycosylated Hemoglobin (HbA1c) level were measured using atomic absorption spectrometry and Ichroma. Results: The results showed significant decrease in serum chromium level in type II DM patients (0.0151±0.005) when compared with healthy group (0.122±0.691) with p-value (0.002). In addition to that there was significant decrease in mean concentration of serum chromium level in controlled diabetic patients (0.0206± 0.003) when compared with uncontrolled diabetic patients (0.0120±0.002) with P-value (0.04).Also there was significant positive correlation between chromium level and Body Mass Index (BMI) (R-value 0.450, P-value 0.014), and significant negative correlation between chromium level and age (R-value- 0.660, P-value 0.011) , a significant strong negative correlation between chromium level and HbA1c (R-value -0.843, P-value 0.0260). Conclusion: The study concluded that, serum chromium level is significantly decrease in type II DM.

Chemical Treatment of Liquid Waste Generated from Leather Tannery Industry by Using Alum as Coagulant Material

The tannery industry generally produces trivalent chromium waste (Cr3 +) and hexavalent chromium (Cr6 +). This waste before being released into the environment must meet quality standards according to KEPMENLH no.51 / MENLH / 10/1995 concerning liquid quality standards for industrial activities which says the maximum total chromium content is 0.6 ppm. This study aims to reduce the levels of Chromium in waste produced by the leather tanning industry by using alum coagulants. This research uses simulation waste which is made based on the results of BPPT analysis of waste in the leather tanning industry in Tangerang city, namely CV "Lengtat Tangerang Leather". The method used in this research is coagulation-flocculation with alum as a coagulant and lime as an alum reaction assistant in the form of hydroxide ions. The parameters observed in this study were the pH adjustment and the ratio of alum mass to lime mass. From the results of the study it was found that the decrease in the best chromium content for Cr + 3 occurred at a ratio of 5 and pH 8.2 which resulted in a chromium content of 0.0076 ppm with a decrease in percentage of 99.95%. As for the Cr6 + test, at a ratio of 3 and pH 6.4 the chromium content showed a value of 0.4110 ppm. The lowest chromium level occurs at a ratio of 5 and pH of 5.8 which results in a chromium level of 0.3341 ppm with a decrease percentage of 56.61%.

Serum Chromium Levels are Higher in Peritoneal Dialysis than in Hemodialysis Patients

BackgroundAn elevation in serum chromium levels in individuals treated with renal replacement therapy has been previously described, but chromium levels have not been systematically studied in patients treated with different dialysis modalities. The aim of this study was to compare serum chromium levels in patients treated with chronic peritoneal dialysis (PD) and hemodialysis (HD).MethodsWe studied 169 chronic dialysis patients in a single medical center, of which 148 were treated with HD and 21 with PD. Serum chromium levels were measured by atomic absorption spectrometry. Residual renal function was accessed using a timed urine collection for the measurement of urine output and calculation of glomerular filtration rate (GFR).ResultsThe median (interquartile range) serum chromium level was significantly higher in patients treated with PD than in patients treated with HD: 5.00 (3.24 – 6.15) vs 1.83 (1.29 – 2.45) mcg/L, p < 0.001. In a univariate analysis, serum chromium level was associated with PD modality: Exp (B) 7.46 (95% confidence interval [CI] 2.1 – 26.4), p = 0.002. The association of PD modality with serum chromium level was even more significant using a multivariate logistic regression model: odds ratio (OR) 11.87 (95% CI 2.85 – 49.52), p = 0.001 after adjustment for age, gender, diabetes, smoking, dialysis vintage, use of diuretics, and residual renal function.ConclusionsIn patients treated with chronic dialysis, serum chromium levels are higher in patients treated with PD than in those treated with HD.