Phenotypes of professional bronchial asthma from the standpoint of spirometry

The aim of the study was to conduct a comparative analysis of spirometric indicators of respiration in various phenotypes of occupational bronchial asthma. Materials and methods. At the clinical stage of the work, a comprehensive clinical, radiological, spirographic, echocardiographic, immunological and molecular genetic examination of 170 patients of the main groups and 50 individuals of the control group was carried out. The results of the study. Dynamic determination of the speed indicators of forced exhalation in various phenotypes of occupational bronchial asthma can improve the diagnosis of obstructive disorders in this pathology, optimize the choice of treatment tactics, and predict the course of this pathology.

COMPARATIVE CHARACTERISTICS OF THE EXTERNAL BREATHING PARAMETERS OF YOUNG ATHLETES IN CYCLIC SPORTS

At present, one of the main tasks of the state is to develop and improve the system of health protection and quality of life of the younger generation. In this regard, the search for simple non-invasive methods of monitoring the health of children, and especially young athletes at various stages of their competitive activity, is of great importance. It is known that the leading place among the factors influencing sports performance is occupied by a number of authors with the peculiarities of metabolic processes of sportsmen [1, 2], hemodynamics [3, 4], neuromuscular activation [5, 6], activity of the central nervous system [7, 8]. It has been shown that systematic repetition of dosed muscle load increases not only physical endurance in sportsmen but also their body resistance to hypoxia [4]. However, to date, the literature practically lacks data from complex controlled studies on the assessment of the functional state of the body in young athletes. At the same time, it should be noted that changes in the parameters of external respiration are one of the most important markers of medical and biological control of training, both for beginners and highly qualified sportsmen [9, 10]. In our opinion, studying the features of external respiration in athletes of cyclic sports of different orientation can be useful in building schemes, choosing modes and methods of their training process. In this connection, the purpose of the present research was the comparative characteristic of the external breathing system of young sportsmen of cyclic sports of orienteers and track-and-field athletes who are at the stage of a basic training mesocycle. The study was carried out with the participation of 20 young male and female athletes engaged in athletics and sports orientation. The 1st group (10 people) included athletes engaged in track and field athletics, athletes stewards (runners for 800–3000 meters, the average distance during training from 1500 to 4000 meters, pace – about 5 minutes per 1 km.), the 2nd group (10 people) – athletes engaged in orienteering (the average distance of running from 3000 to 6000 meters, pace – about 6–7 minutes per 1 km.). The age of athletes was within 13–15 years. The external breathing apparatus is most developed for orienteering athletes who have elements of staying load in the training process, with predominance of aerobic type of energy exchange, while for athletes-athletes the most characteristic was high power of forced exhalation and values of maximum ventilation of the lungs, which is due to a high degree of adaptation of these athletes to anaerobic load of high intensity. Young orienteering athletes recorded higher values in the «tranquil breathing» test as compared to track and field athletes. Thus, YEL on the average is 11.97 % (p<0.05) higher than in the group of track and field athletes, and the indicators of ROV – by 20.30 % (p<0.05) higher than the values obtained from volunteers involved in athletics. The probable mechanism of such differences may be that the efficiency of the training process of athletics athletes, in contrast to orienteers, is equally related to both anaerobic and aerobic types of energy exchange, and less dependent on the functioning of the external respiratory apparatus, which is reflected in the lower values of GEL and RO in these athletes, compared to young orienteering athletes, characterized by a greater contribution of aerobic type of energy exchange. In the tests «forced exhalation» and «maximum ventilation of the lungs» the orienteers registered lower values of the studied indices (FSEL in – by 17,08 % (p<0,05), OFV1 – by 24,84 % (p<0,05), ratio OFV1/FSEL – by 2,67 % (p<0,05), MVL – by 29,21 % (p<0,05) lower than in the group of athletes), which is due to a higher degree of formation of adaptation mechanisms of oxygen debt compensation at high intensity physical activity in comparison with orienteering sportsmen, whose training process is mostly connected with long medium intensity loads.

Age peculiarities of spirometric indices within the juvenile period of ontogenesis

In the modern world, there are many causes (reducing the elasticity of the lungs, reducing bronchial tubes, reducing the strength of the respiratory muscles) that affect the parameters of external respiration. Knowledge of age, sexual and regional features of spirometric indicators helps to differentiate and detect the degree of disturbance of respiratory biomechanics and to choose effective treatments that are most appropriate for established violations. The purpose of the work is to establish the age-old peculiarities of the spirographic indexes of virtually healthy young men and women within the juvenile period of ontogenesis. We conducted a survey of 141 young women (from 16 to 20 years of age) and 154 young men (from 17 to 21 years) of adolescence. The spirographic study was conducted according to the generally accepted methodology of the American Association of Pulmonologists adopted in 1994 on the device Medgraphics Pulmonary Function System 1070 series. The analysis of the obtained results was carried out with the help of the license program "Statistica 5.5" using nonparametric methods of estimating indicators. The progressive age dynamics of the vital capacity, forced vital capacity, forced capacity of the lungs on the inhalation, volume exhalation velocity was detected in young women in 25% and 50% respectively of the forced vital capacity, the average expiration flow, the residual volume of exhalation and the forced inspiratory flow, respectively is 50% of exhalation from the forced vital capacity. In the last year (20 years) of the youthful period of ontogenesis in young women, the maximum arbitrary ventilation of the lungs is increased, the volume exhalation rate is 75%, and from 75% to 85% of exhalation from the forced vital capacity, the one-second volume of forced exhalation and maximal peak flow of exhalation. Within the juvenile period of ontogenesis in young men, the vital capacity of the lungs increases, the maximum arbitrary ventilation of the lungs and the maximum peak flow of exhalation. Only in the last year of the youthful period of ontogeny (21 years) in young men there is an increase in forced vital capacity, volume exhalation velocity, respectively, in 25% of the forced vital capacity, the residual volume of exhalation, one-second volume of forced exhalation was observed at the end.