ФРОНТОВОЙ БЫТ ВЕЛИКОЙ ОТЕЧЕСТВЕННОЙ ВОЙНЫ: СТРУКТУРА И ОСОБЕННОСТИ

Фронтовая повседневность определяется автором как совокупность опасности боя и повседневности быта во всём многообразии их типичных и уникальных проявлений. В данной статье рассматриваются особенности фронтового быта Красной Армии в период Великой Отечественной войны на основе эго-документов (писем, дневников, мемуаров) и материалов «устной истории» – воспоминаний-интервью её участников, представителей разных родов войск и военных профессий, принадлежащих к рядовому, младшему и среднему командному составу. Показано, что от качества солдатского быта, его организации в экстремальных военных условиях во многом зависел моральный дух войск и их боеспособность, а недостаточное внимание к отдельным бытовым факторам негативно сказывалось на ходе боевых действий или приводило к неоправданно большим потерям. Изучение фронтовой повседневности, ее тяжести и противоречивости, через мироощущение и судьбы отдельных фронтовиков позволяет глубже понять «человеческий ракурс» новейшей военной истории, тот трудноуловимый субъективный фактор, который в экстремальных условиях войны мог неожиданно перевесить все факторы материальные и оказаться «последней каплей», склоняющей чашу весов в сторону побед или поражений. Front-line life is a combination of the danger of battle and everyday life in all the variety of their typical and unique manifestations. This article examines the specifics of the front-line life of the Red Army during the Great Patriotic War based on ego-documents (letters, diaries, memoirs) and on “oral history” – memoirs-interviews of its participants belonging to the armed forces and military professions of the rank-and-file and the command staff. It is shown that the morale of the troops and their fighting capacity largely depended on the quality of the soldier’s life, its organization in extreme military conditions. Insufficient attention to certain household factors negatively affected the course of hostilities or led to unjustifiably large losses. The study of the front-line everyday life in all its diversity and controversy through the eyes and the fates of individual front-line soldiers allows us to better understand the “human perspective” of recent military history, the elusive subjective factor that in extreme conditions could unexpectedly outweigh all material factors and turn out to be the “last straw” that tips the scales in favor of victories or defeats.

The impact of time-to-castration resistance on survival in patients with metastatic hormone-naïve prostate cancer: A multicenter retrospective study.

213 Background: To evaluate the prognostic impact of time to castration resistance (TCR) in patients with metastatic hormone-naïve prostate cancer (mHNPC). Methods: We retrospectively evaluated 283 mHNPC patients with metastatic castration-resistant prostate cancer (mCRPC) who were initially treated with androgen deprivation therapy as metastatic hormone-naïve prostate cancer in 14 hospitals between September 2008 and October 2018. Overall survival (OS) and OS after castration resistance (OS-CR) were compared between the <12 months (TCR <12M) and ≥12 months (TCR ≥12M). The association between the first-line life-prolonging therapy (docetaxel or new androgen receptor-targeted agents: ART) and TCR on OS-CR was investigated using multivariate Cox regression analysis via inverse probability of treatment weighting (IPTW) model. Results: Median age and time to CRPC were 72 years and 12 months, respectively. The number of patients in the TCR<12M and ≥12M groups were 137 and 146, respectively. Of 283, baseline parameters such as age, extent of disease (EOD), hemoglobin (Hgb), lactate dehydrogenase (LDH), and serum albumin levels were significantly differences in between the groups. We observed significantly poor OS and OS-CR in the TCR <12M group than those in the TCR ≥12M group. First-line docetaxel therapy did not significantly improved OS-CR regardless of TCR. Background (age, ECOG PS, GS, Hgb, tumor volume, serum data, and TCR)-adjusted multivariate Cox regression analyses showed that first-line docetaxel therapy was significantly associated with shorter OS-CR than first-line ART therapy in the TCR <12M group. Conclusions: The prognostic impact of TCR on OS was significant. However, the association between the first-line life-prolonging therapy and TCR on OS need further study.

Blockchain and it’s Applications in Various Fields

Automatic international has delivered efficiencies, new ingenious items, and close customer connections all round with the aid of the a success usage of transportable, IoT (net of factors), on-line life, exam and cloud innovation to create models for higher selections. Blockchain is as of late presented and altering the computerized global conveying some other point of view to security, flexibility and effectiveness of frameworks. at the same time as at the start promoted via Bitcoin, Blockchain is considerably greater than an established order for virtual foreign money. It gives a secure technique to trade any sort of right, management, or change. Mechanical development regularly is based upon confided in organizations; but expanding manage, cybercrime and extortion are repressing extension. To cope with these difficulties, Blockchain will empower more mild-footed esteem chains, quicker object improvements, nearer consumer connections, and swifter incorporation with the IoT and cloud innovation. Facilitate Blockchain furnishes a decrease price of trade with a believed contract checked without mediation from outsider